{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:36:34Z","timestamp":1762252594750,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:00:00Z","timestamp":1503273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Periodontal furcation defects are usually addressed by the placement of a physical barrier which may limit the regenerative potential of periodontal wounds. This study morphometrically quantified the regenerative effect of brain\u2010derived neurotrophic factor (BDNF) in furcation defects in a non\u2010human primate model. Grade II furcation defects (with and without induced inflammation prior to surgery) were created on the first and second molars of eight non\u2010human primates. Defects were treated with open flap debridement and subsequently filled with either: Group A; BDNF (500 \u00b5g mL<jats:sup>\u22121<\/jats:sup>) in high\u2010molecular weight\u2010hyaluronic acid (HMW\u2010HA), Group B; BDNF (50 \u00b5g mL<jats:sup>\u22121<\/jats:sup>) in HMW\u2010HA, Group C; HMW\u2010HA acid only, Group D; unfilled defect, or Group E; BDNF (500 \u00b5g mL<jats:sup>\u22121<\/jats:sup>) in saline. Periodontal wound healing was observed every 2 weeks by computed\u2010tomography. At 11 weeks all animals were sacrificed and maxillary and mandibular block biopsies were referred for nondecalcified histology. Linear measurements of new cementum (cellular and acellular) and periodontal ligament (PDL) formation were performed. Computerized\u2010tomography reconstruction and software quantification demonstrated successful bone fill for all groups. However, histometric assessment demonstrated significantly higher level of total periodontal regeneration for the 500 \u00b5g mL<jats:sup>\u22121<\/jats:sup> BDNF HMW\u2010HA relative to all other groups. No significant differences in cementogenesis were observed among groups. Significantly higher acellular cementum formation was observed for sites where inflammation was not induced prior to surgical procedures. While all groups experienced similar bone fill and cementogenesis, the 500 \u00b5g mL<jats:sup>\u22121<\/jats:sup> BDNF HMW\u2010HA appeared to most effectively repair PDL (minimum increase of \u223c22% relative to all groups; over 200% relative to unfilled defects). \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1611\u20131617, 2018.<\/jats:p>","DOI":"10.1002\/jbm.b.33977","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T15:34:47Z","timestamp":1503329687000},"page":"1611-1617","source":"Crossref","is-referenced-by-count":12,"title":["Regeneration of the cementum and periodontal ligament using local BDNF delivery in class II furcation defects"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1945-1074","authenticated-orcid":false,"given":"Ryo","family":"Jimbo","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Odontology Malm\u00f6 University  Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Biomimetics New York University College of Dentistry New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Tovar","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Biomimetics New York University College of Dentistry New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Marin","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry UNIGRANRIO Duque de Caxias Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Neiva","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Florida Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estevam A.","family":"Bonfante","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontology University of Sao Paulo\u2013Bauru School of Dentistry Bauru SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malvin N.","family":"Janal","sequence":"additional","affiliation":[{"name":"Department of Public Health and Epidemiology New York University College of Dentistry New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugues","family":"Contamin","sequence":"additional","affiliation":[{"name":"Researcher at Cynbiose, 69280 Marcy l'Etoile Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo G.","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Biomimetics New York University College of Dentistry New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00317.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.3.157"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(96)00127-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084845"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.12.750"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1993.tb00202.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-9657.2002.00118.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00366.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00642.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00191.x"},{"volume-title":"Glickman's Clinical Periodontology","year":"1990","author":"Glickman I","key":"e_1_2_6_12_1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2010.0070"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1979.50.7.366"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12715"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2011.11.032"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb00651.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.1514"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.11s.1157"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.4.370"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.2.262"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2005.00799.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00731-0"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5193(86)80076-5"},{"issue":"9","key":"e_1_2_6_25_1","first-page":"1618","article-title":"Brain\u2010derived neurotrophic factor enhances periodontal tissue regeneration. 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