{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T20:50:39Z","timestamp":1768078239950,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:00:00Z","timestamp":1505260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","award":["FINEP\u201001.10.0659.00"],"award-info":[{"award-number":["FINEP\u201001.10.0659.00"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two scaffolds of chitosan\/sodium alginate\/hydroxyapatite (Ch\/NaAlg\/Hap) 1:1:0.2 and 1:1:0.6 were evaluated in the prevention of bisphosphonate\u2010induced jaw osteonecrosis. Two groups of rats (<jats:italic>n<\/jats:italic>\u2009=\u200924, according to the euthanasia time: 15 or 30 days after the last Zoledronic acid (ZA) administration) were subdivided in four subgroups (<jats:italic>n<\/jats:italic>\u2009=\u20096): I \u2013 Control (saline\u2009+\u2009teeth extraction); II \u2013 ZA 0.6 mg\/kg\u2009+\u2009teeth extraction; III \u2013 ZA\u2009+\u2009teeth extraction\u2009+\u2009scaffold 1:1:0.2; IV \u2013 ZA\u2009+\u2009teeth extraction\u2009+\u2009scaffold 1:1:0.6. Jaws were evaluated histologically and blood was evaluated for hematological and biochemical parameters. Histopathology showed significant osteonecrosis in AZ group. The scaffold's implantation, despite the inflammatory process, were able to prevent the osteonecrosis. In the 15\u2010day euthanasia group, an increase in red blood cells and platelets was observed in the subgroup II. Hemoglobin and hematocrit decreased in subgroup IV compared to II. Hepatic transaminases and creatinine concentration increased significantly in subgroup II. Calcium concentration increased in subgroup IV compared to II. In the 30\u2010day euthanasia group, no differences among the groups were observed for any parameter. Scaffolds proved to be efficient and safe to liver and kidney function. Some hematological parameters were altered by the scaffold, but returned to normal concentrations over time. \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1799\u20131808, 2018.<\/jats:p>","DOI":"10.1002\/jbm.b.33995","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T13:56:41Z","timestamp":1505311001000},"page":"1799-1808","source":"Crossref","is-referenced-by-count":11,"title":["Safety and efficacy of hydroxyapatite scaffold in the prevention of jaw osteonecrosis <i>in vivo<\/i>"],"prefix":"10.1002","volume":"106","author":[{"given":"Adriana Duarte","family":"de Almeida","sequence":"first","affiliation":[{"name":"Laboratory of Toxicological Research, University of Sorocaba (Uniso) Sorocaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Gomes","family":"Leite","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicological Research, University of Sorocaba (Uniso) Sorocaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Vin\u00edcius","family":"Chaud","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Nanotechnology University of Sorocaba (Uniso) Sorocaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia de Ara\u00fajo","family":"Rebelo","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Nanotechnology University of Sorocaba (Uniso) Sorocaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliane Cristine Ferreira de Souza","family":"Borges","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Nanotechnology University of Sorocaba (Uniso) Sorocaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabia Judice Marques","family":"Viroel","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicological Research, University of Sorocaba (Uniso) Sorocaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandre","family":"Hataka","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine and Animal Science S\u00e3o Paulo State University (UNESP) Botucatu S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Grotto","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicological Research, University of Sorocaba (Uniso) Sorocaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000380991"},{"key":"e_1_2_7_3_1","volume-title":"Modeling and Remodeling in Bon\u00e9 Tissue","author":"Ruimerman R.","year":"2005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.10.1859"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/00912709922008272"},{"issue":"2","key":"e_1_2_7_6_1","first-page":"23","article-title":"Anti\u2010tumor potential of biphosphonates","volume":"95","author":"Green JR.","year":"2000","journal-title":"Med Klin"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.19.1.0325"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.07.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000615)88:12 <2961::AID-CNCR12>3.0.CO;2-L"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0843"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.99.132"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2004.02.004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1138\/20060229"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4236\/health.2011.39095"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.06.004"},{"issue":"1","key":"e_1_2_7_17_1","first-page":"52","article-title":"Bisphosphonate\u2010related osteonecrosis of the jaw in patients with myeloma","volume":"13","author":"Coss\u00edo PI","year":"2008","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_7_18_1","unstructured":"RebeloMA.Desenvolvimento e caracteriza\u00e7\u00e3o de scaffold com potencial para aplica\u00e7\u00e3o na regenera\u00e7\u00e3o de tecido \u00f3sseo. 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