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Our previous study has found that the 316L type Cu bearing stainless steel (316L\u2010Cu SS) showed antimicrobial activity and anti\u2010encrustation performance when it was used for relieving urethral obstructer. However, whether it can reduce the occurrence of fibrosis or not, we need further investigation to compare the cellular and molecular responses of human urethral scar fibroblast cells (USFCs) on 316L\u2010Cu SS and medical grade 316L stainless (316L SS, as a control). [3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)\u20105\u2010(3\u2010carboxymethoxyphenyl)\u20102\u2010(4\u2010 sulfophenyl)\u2010 2H\u2010tetrazolium (MTS) and Transwell were used to assess the cellular responses, which confirmed that 316L\u2010Cu SS could inhibit proliferation and migration of USFCs. Molecular expressions of fibrosis were evaluated by western blot, real\u2010time quantitative polymerase chain reaction (qPCR), and Cu\/Zn superoxide dismutase (CuZnSOD) measurement. The results indicated that up\u2010regulating of CuZnSOD attenuated the transforming growth factor\u2010\u03b21 expression and phosphorylation of Smad3 after exposure to 316L\u2010Cu SS. Besides, the content of collagen type I (COL1) and collagen type III (COL3) secreting into the culture medium measured by enzyme\u2010linked immunosorbent assay were in accord with the results of messenger ribonucleic acids. Both of them exhibited lower levels of COL1\/COL3 exposure to 316L\u2010Cu SS, demonstrating the inhibitory performance of 316L\u2010Cu SS against fibrosis. \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2019\u20132028, 2018.<\/jats:p>","DOI":"10.1002\/jbm.b.34005","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T17:29:15Z","timestamp":1508952555000},"page":"2019-2028","source":"Crossref","is-referenced-by-count":4,"title":["Anti\u2010fibrotic function of Cu\u2010bearing stainless steel for reducing recurrence of urethral stricture after stent implantation"],"prefix":"10.1002","volume":"106","author":[{"given":"Jing","family":"Zhao","sequence":"first","affiliation":[{"name":"Institute of Metal Research, Chinese Academy of Sciences Shenyang 110016 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Metal Research, Chinese Academy of Sciences Shenyang 110016 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