{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T17:40:10Z","timestamp":1719510010328},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T00:00:00Z","timestamp":1507593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To create anti\u2010adhesive materials to be more effective and safer, we developed a thermally cross\u2010linked gelatin film that showed superior anti\u2010adhesive effects with excellent peritoneal regeneration. However, it may act as a convenient scaffold for tumor cell growth, thereby accelerating peritoneal dissemination when used in surgery for abdominal tumors. In this study, we tried to clarify this issue using mouse carcinomatous peritonitis models. First, we examined the<jats:italic>in vitro<\/jats:italic>tumor cell growth of mouse B16 melanoma or Colon26 cells on the gelatin film or the conventional hyarulonate\/carboxymethylcellulose film. Tumor cell growth on each film was significantly lower than that of the control (no film). Next, we conducted the following<jats:italic>in vivo<\/jats:italic>experiments: After the parietal peritoneum was partially removed and covered with each film or without any film, mice were inoculated intraperitoneally with B16 melanoma or Colon26\/Nluc cells expressing NanoLuc luciferase gene. At 7 days after the operation, we measured the weight of B16 melanoma tumors or the NanoLuc activity of Colon26\/Nluc cells using<jats:italic>in vivo<\/jats:italic>imaging at the injured sites. There were no significant differences in the weight of the tumors and the NanoLuc activity among the three groups. We also observed the survival time of mice receiving the same operation and treatments. There was no significant difference in the survival time among the three groups. These results suggest that the gelatin film will likely not accelerate peritoneal dissemination as a convenient scaffold for tumor cell growth when used in surgery for abdominal tumors. \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2122\u20132130, 2018.<\/jats:p>","DOI":"10.1002\/jbm.b.34017","type":"journal-article","created":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T14:48:39Z","timestamp":1507646919000},"page":"2122-2130","source":"Crossref","is-referenced-by-count":0,"title":["The influences of a novel anti\u2010adhesion device, thermally cross\u2010linked gelatin film on peritoneal dissemination of tumor cells: The<i>in vitro<\/i>and<i>in vivo<\/i>experiments using murine carcinomatous peritonitis models"],"prefix":"10.1002","volume":"106","author":[{"given":"Hiroe","family":"Miyamoto","sequence":"first","affiliation":[{"name":"Department of Medical Life Systems, Faculty of Life and Medical Sciences Doshisha University Kyotanabe Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tsujimoto","sequence":"additional","affiliation":[{"name":"Department of Medical Life Systems, Faculty of Life and Medical Sciences Doshisha University Kyotanabe Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsunehito","family":"Horii","sequence":"additional","affiliation":[{"name":"Department of Medical Life Systems, Faculty of Life and Medical Sciences Doshisha University Kyotanabe Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Ozamoto","sequence":"additional","affiliation":[{"name":"Kusatsu General Hospital Kusatsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe","family":"Ueda","sequence":"additional","affiliation":[{"name":"Kainan Hospital Yatomi Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshitaka","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Medical Life Systems, Faculty of Life and Medical Sciences Doshisha University Kyotanabe Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Department of Medical Life Systems, Faculty of Life and Medical Sciences Doshisha University Kyotanabe Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akeo","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Medical Life Systems, Faculty of Life and Medical Sciences Doshisha University Kyotanabe Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"10","article-title":"Biochemical events in peritoneal tissue repair","volume":"577","author":"diZerega GS.","year":"1997","journal-title":"Eur J Surg"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.6.547"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.12.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i41.4545"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)09337-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(99)70208-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2004.10.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.6.1358"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10397-012-0742-8"},{"key":"e_1_2_7_11_1","unstructured":"Genzyme Corporation C MA. 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