{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:09:16Z","timestamp":1791623356226,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T00:00:00Z","timestamp":1509926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EB04315"],"award-info":[{"award-number":["R01EB04315"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01EB021214"],"award-info":[{"award-number":["U01EB021214"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Novel biomaterials for medical device applications must be stable throughout all stages of preparation for surgery, including sterilization. There is a paucity of information on the effects of sterilization on sub\u201010 nm\u2010thick polymeric surface coatings suitable for silicon\u2010based bioartificial organs. This study explores the effect of five standard sterilization methods on three surface coatings applied to silicon: polyethylene glycol (PEG), poly(sulfobetaine methacrylate) (pSBMA), and poly (2\u2010methacryloyloxyethyl phosphorylcholine) (pMPC). Autoclave, dry heat, hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) plasma, ethylene oxide gas (EtO), and electron beam (E\u2010beam) treated coatings were analyzed to determine possible polymer degradation with sterilization. Poststerilization, there were significant alterations in contact angle, maximum change resulting from H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    (\u0394\u2009\u2212\u200914\u00b0), autoclave (\u0394\u2009+\u200915\u00b0), and dry heat (\u0394\u2009+\u200923\u00b0) treatments for PEG, pSBMA, and pMPC, respectively. Less than 5% coating thickness change was found with autoclave and EtO on PEG\u2010silicon, E\u2010beam on pSBMA\u2010silicon and EtO treatment on pMPC\u2010silicon. H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    treatment resulted in at least 30% decrease in thickness for all coatings. Enzyme\u2010linked immunosorbent assays showed significant protein adsorption increase for pMPC\u2010silicon following all sterilization methods. E\u2010beam on PEG\u2010silicon and dry\u2010heat treatment on pSBMA\u2010silicon exhibited maximum protein adsorption in each coating subset. Overall, the data suggest autoclave and EtO treatments are well\u2010suited for PEG\u2010silicon, while E\u2010beam is best suited for pSBMA\u2010silicon. pMPC\u2010silicon was least impacted by EtO treatment. H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    treatment had a negative effect on all three coatings. These results can be used to determine which surface modifications and sterilization processes to utilize for devices\n                    <jats:italic>in vivo<\/jats:italic>\n                    . \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2327\u20132336, 2018.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.34039","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T03:15:38Z","timestamp":1509938138000},"page":"2327-2336","source":"Crossref","is-referenced-by-count":23,"title":["Sterilization effects on ultrathin film polymer coatings for silicon\u2010based implantable medical devices"],"prefix":"10.1002","volume":"106","author":[{"given":"Zohora","family":"Iqbal","sequence":"first","affiliation":[{"name":"Department of Bioengineering &amp; Therapeutic Sciences University of California \u2010 San Francisco (UCSF) San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willieford","family":"Moses","sequence":"additional","affiliation":[{"name":"Department of Surgery UCSF San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Nephrology UCSF San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Bioengineering &amp; Therapeutic Sciences University of California \u2010 San Francisco (UCSF) San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Fissell","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuvo","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Bioengineering &amp; Therapeutic Sciences University of California \u2010 San Francisco (UCSF) San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sse.2006.03.023"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-0286(02)00032-3"},{"key":"e_1_2_8_4_1","first-page":"263","volume-title":"BioMEMS and Biomedical Nanotechnology","author":"Desai T","year":"2007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-0344(00)00063-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2005.7.151"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-7388(99)00062-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23679"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7LC00096K"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1109\/SENSOR.2009.5285603"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05532"},{"key":"e_1_2_8_12_1","first-page":"1","article-title":"Healthcare Infection Control Practices Advisory Committee (HICPAC). Guideline for disinfection and sterilization in healthcare facilities, 2008","author":"Rutala WA","year":"2008","journal-title":"Centers for Disease Control (CDC)"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2009.00662.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159526"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-011-0256-y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00113-3"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2008.09.039"},{"issue":"4","key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/MAT.0b013e3181d98cf8","article-title":"Silicon induces minimal thromboinflammatory response during 28\u2010day intravascular implant testing","volume":"56","author":"Melvin ME","year":"2010","journal-title":"ASAIO J"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2003.10.007"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(98)00026-X"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2010.03.027"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4005(01)00925-X"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200305830"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2013.02.019"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.09.020"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2004.01.034"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.07.039"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/la062175d"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/la052851w"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856208X386444"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004120"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00007-8"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2008.06.013"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30874"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31811"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1163\/092050609X12578498982998"},{"key":"e_1_2_8_37_1","unstructured":"Centers for Disease Control and Prevention\u2010Guidelines for Disinfection and Sterilization in Healthcare Facilities (Other Sterilization Methods);2016.https:\/\/www.cdc.gov\/infectioncontrol\/guidelines\/disinfection\/sterilization\/other-methods.html. Accessed May 6 2017."},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2009.12.035"},{"key":"e_1_2_8_39_1","volume-title":"Thermal Degradation of Polymeric Materials","author":"Krzysztof P","year":"2005"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0032-3861(97)88175-X"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.4236\/jbnb.2011.24045"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(80)90037-X"},{"key":"e_1_2_8_43_1","first-page":"43","volume-title":"Fabad J Pharm Sci","author":"Silindir M","year":"2009"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009938507935"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4002532"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.34039","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.34039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T10:19:50Z","timestamp":1695032390000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.34039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,6]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1002\/jbm.b.34039"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.34039","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,6]]}}}