{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:14:49Z","timestamp":1761218089008},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T00:00:00Z","timestamp":1525651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"FINEP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, we report the production and characterization of tracheal stents composed of polydimethylsiloxane\/nanostructured calcium phosphate composites obtained by reactive synthesis. Tracheal stents were produced by transfer molding, and <jats:italic>in vivo<\/jats:italic> tests were carried out. PDMS was combined with H<jats:sub>3<\/jats:sub>PO<jats:sub>4<\/jats:sub> and Ca(OH)<jats:sub>2<\/jats:sub> via an <jats:italic>in situ<\/jats:italic> reaction to obtain nanoparticles of calcium phosphate dispersed within the polymeric matrix. The incorporation of bioactive inorganic substances, such as calcium phosphates, improved biological properties, and the <jats:italic>in situ<\/jats:italic> reaction allowed tight coupling of particles to the matrix. Results showed the presence of the nanoparticles of DCPA and CDHA. The porosity generated during mixing decreased the tensile strength and tear properties. Composites presented higher values of cell viability compared with those for PDMS. <jats:italic>In vivo<\/jats:italic> tests indicated the presence of inflammatory tissue 30 days after implantation in both cases. Thus, the present biomaterial shows potential for application in tracheal disease, however further evaluation is needed. \u00a9 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. \u00a9 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 545\u2013553, 2019.<\/jats:p>","DOI":"10.1002\/jbm.b.34145","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T03:11:34Z","timestamp":1525662694000},"page":"545-553","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Polydimethylsiloxane\/nano calcium phosphate composite tracheal stents: Mechanical and physiological properties"],"prefix":"10.1002","volume":"107","author":[{"given":"K\u00e9tner","family":"Bendo Dem\u00e9trio","sequence":"first","affiliation":[{"name":"PPGCEM, Post\u2010Graduate Program in Science and Engineering Materials UNESC\u2013University of the South of Santa Catarina Crici\u00fama SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta Justina","family":"Giotti Cioato","sequence":"additional","affiliation":[{"name":"HCPA, Hospital de Cl\u00ednicas de Porto Alegre, Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Moreschi","sequence":"additional","affiliation":[{"name":"HCPA, Hospital de Cl\u00ednicas de Porto Alegre, Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme Augusto","family":"Oliveira","sequence":"additional","affiliation":[{"name":"HCPA, Hospital de Cl\u00ednicas de Porto Alegre, Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Lorenzi","sequence":"additional","affiliation":[{"name":"HCPA, Hospital de Cl\u00ednicas de Porto Alegre, Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine","family":"Hehn de Oliveira","sequence":"additional","affiliation":[{"name":"HCPA, Hospital de Cl\u00ednicas de Porto Alegre, Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amar\u00edlio","family":"Vieira de Macedo Neto","sequence":"additional","affiliation":[{"name":"HCPA, Hospital de Cl\u00ednicas de Porto Alegre, Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Roberto","family":"Stefani Sanches","sequence":"additional","affiliation":[{"name":"HCPA, Hospital de Cl\u00ednicas de Porto Alegre, Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rogerio Gastal","family":"Xavier","sequence":"additional","affiliation":[{"name":"HCPA, Hospital de Cl\u00ednicas de Porto Alegre, Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds Alberto","family":"Loureiro dos Santos","sequence":"additional","affiliation":[{"name":"LABIOMAT, Laboratory of Biomaterials, Department of Materials Federal University of Rio Grande do Sul, UFRGS Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pi.783"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2009.04.029"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00208-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.06.031"},{"key":"e_1_2_7_6_1","first-page":"1","article-title":"Desenvolvimento de comp\u00f3sitos polidimetilsiloxano\/fosfatos de c\u00e1lcio","author":"Ferreira OJB.","year":"2012","journal-title":"Master dissertation"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2013.12.027"},{"key":"e_1_2_7_8_1","unstructured":"SantosLA FerreiraOJB SousaVC Macedo NetoAV OliveiraHG SaueressigMG SanchesPRS FerreiraPRW SilvaJrEMS.Comp\u00f3sito nanoestruturado de fosfato de c\u00e1lcio e borracha de silicone. 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