{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:28:35Z","timestamp":1787358515671,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T00:00:00Z","timestamp":1533513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201206240123"],"award-info":[{"award-number":["201206240123"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Radiation crosslinking decreases the wear of ultrahigh molecular weight polyethylene (UHMWPE) used in total joint implants and creates residual free radicals, which are the precursors of oxidative degradation. It is desirable to obtain a simultaneously wear\u2010 and oxidation\u2010resistant UHMWPE in order to prolong the longevity of implants. In this study, we hypothesized that the oxidative stability of a vitamin E\u2010containing, wear resistant UHMWPE can be improved by limiting the exposure of the antioxidant to radiation to maximize its activity. We blended UHMWPE powder with 0.1 wt % vitamin\u2010E and irradiated these powder blends (XPE). We further blended and consolidated uncrosslinked 0.1 wt % vitamin E\u2010blended UHMWPE with XPE and assessed the effects of radiation dose used for XPE and XPE content in the formulation on pin\u2010on\u2010disk wear resistance, static mechanical properties, and squalene\u2010initiated accelerated thermal aging. The wear rate decreased significantly with increasing XPE content in UHMWPE\/XPE and increasing radiation dose used in the XPE preparation. The UHMWPE\/XPE blends displayed improved oxidation resistance in the presence of the pro\u2010oxidant squalene compared to vitamin E\u2010blended UHMWPE irradiated to 125 kGy after consolidation. Strength and toughness of the UHMWPE\/XPE blends decreased with increasing radiation dose and increasing XPE content; and these were comparable to those measured with the consolidated and irradiated vitamin E\u2010blended UHMWPE. Blending UHMWPE with XPE is a feasible approach to create a wear resistant UHMWPE with more active vitamin E available for long\u2010term oxidative protection of the polymer as the radiation exposure of the vitamin\u2010E in the vitamin E\u2010blended UHMWPE matrix is minimized. \u00a9 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 716\u2013723, 2019.<\/jats:p>","DOI":"10.1002\/jbm.b.34165","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T11:00:31Z","timestamp":1533639631000},"page":"716-723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Improved oxidation and wear resistance of ultrahigh molecular weight polyethylene using cross\u2010linked powder reinforcement"],"prefix":"10.1002","volume":"107","author":[{"given":"Jia\u2010Zhuang","family":"Xu","sequence":"first","affiliation":[{"name":"Harris Orthopedic Laboratory Massachusetts General Hospital, 55 Fruit Street Boston Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhun K.","family":"Muratoglu","sequence":"additional","affiliation":[{"name":"Harris Orthopedic Laboratory Massachusetts General Hospital, 55 Fruit Street Boston Massachusetts 02114"},{"name":"Department of Orthopedic Surgery Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"Oral","sequence":"additional","affiliation":[{"name":"Harris Orthopedic Laboratory Massachusetts General Hospital, 55 Fruit Street Boston Massachusetts 02114"},{"name":"Department of Orthopedic Surgery Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00039-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000246547.18187.0b"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(95)00349-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00021-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1717-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2005.07.019"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.01006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.01017"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.32507"},{"key":"e_1_2_6_11_1","unstructured":"MuratogluOK OralE.Patents assignee. 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