{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:35:07Z","timestamp":1789227307345,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Infection associated with an implant is a complication feared in surgery, as it leads to loosening and dysfunction. This report documents an unexpected good bony integration of a porous tantalum shoulder prosthesis despite infection.<\/jats:p><jats:p>A shoulder prosthesis with a porous tantalum glenoidal base plate was retrieved after 3\u2009years of ongoing infection with<jats:italic>Staphylococcus spp<\/jats:italic>. Methyl\u2010methacrylate embedded sections of the retrieved glenoidal component were analyzed by optical and scanning electron beam microscopy (SEM). Bone ongrowth and ingrowth were quantified.<\/jats:p><jats:p>Bone had formed at the implant surface and within the open cell structure of the porous tantalum. The bone implant contact index was 32%. The bone ingrowth or relative bone area within the open structure was 8.2%, respectively 11.9% in the outer 50% of the thickness. Due to the section thickness, bone ongrowth could best be documented in SEM.<\/jats:p><jats:p>Despite long\u2010lasting and ongoing infection, the glenoidal base plate of the prosthesis showed good bony integration upon removal. The bone ingrowth into the porous tantalum was comparable to the values previously reported for the undersurface of retrieved proximal humerus resurfacing implants. Good integration of the implant however did not solve the problem of infection, and related morbidity. \u00a9 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2924\u20132931, 2018.<\/jats:p>","DOI":"10.1002\/jbm.b.34174","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T18:10:46Z","timestamp":1536603046000},"page":"2924-2931","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Successful bony integration of a porous tantalum implant despite longlasting and ongoing infection: Histologic workup of an explanted shoulder prosthesis"],"prefix":"10.1002","volume":"106","author":[{"given":"Peter","family":"Wahl","sequence":"first","affiliation":[{"name":"Division of Orthopaedic and Trauma Surgery Cantonal Hospital Winterthur Switzerland"},{"name":"Department of Septic Surgery BG Trauma Centre Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph M.","family":"Sprecher","sequence":"additional","affiliation":[{"name":"AO Research Institute Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Br\u00fcning","sequence":"additional","affiliation":[{"name":"Department of Septic Surgery BG Trauma Centre Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Meier","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic and Trauma Surgery Cantonal Hospital Winterthur Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Milz","sequence":"additional","affiliation":[{"name":"Institute of Anatomy Ludwig\u2010Maximilians\u2010University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"Gautier","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery HFR Fribourg\u2010Cantonal Hospital Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2307-0397","authenticated-orcid":false,"given":"T","family":"Fintan Moriarty","sequence":"additional","affiliation":[{"name":"AO Research Institute Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/323130"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-1013-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2015.1011983"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90606-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000000262"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3629258"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2008.12.011"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/08927014.2016.1172572"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024827"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2013.06.002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/507633"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00109-13"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181818268"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111305"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31850"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2170"},{"issue":"2","key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.55782\/ane-2014-1984","article-title":"Porous tantalum and tantalum oxide nanoparticles for regenerative medicine","volume":"74","author":"Mohandas G","year":"2014","journal-title":"Acta Neurobiol Exp (Wars)"},{"issue":"4","key":"e_1_2_6_19_1","first-page":"216","article-title":"A porous tantalum trabecular metal: Basic science","volume":"31","author":"Cohen R","year":"2002","journal-title":"Am J Orthop (Belle Mead NJ)"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.04.041"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.81B5.9283"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-012-1640-4"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.01322"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2014.984114"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.97B1.34236"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-200608000-00005"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2004.01.034"},{"key":"e_1_2_6_28_1","volume-title":"AO Principles of Fracture Management","author":"R\u00fcedi TP","year":"2000"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-011-2102-9"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis966"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(01)00094-9"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22902"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-013-4978-2"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002043"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.4.387"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181ca081f"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-015-4322-x"},{"issue":"4","key":"e_1_2_6_38_1","first-page":"297","article-title":"Developmental aspects of fracture healing and the use of pharmacological agents to alter healing","volume":"3","author":"Gerstenfeld LC","year":"2003","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"6","key":"e_1_2_6_39_1","first-page":"573","article-title":"The virulence of Staphylococcus pyogenes for man: A study of the problems of wound infection","volume":"38","author":"Elek SD","year":"1957","journal-title":"Br J Exp Pathol"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/146.4.487"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.09.006"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22114"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000152"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000142"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200101000-00028"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-011-1467-4"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-007-0143-0"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.34174","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.34174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T04:52:51Z","timestamp":1720587171000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.34174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,10]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/jbm.b.34174"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.34174","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,10]]},"assertion":[{"value":"2018-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}