{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:45:41Z","timestamp":1788396341323,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T00:00:00Z","timestamp":1534118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2015\u201304177"],"award-info":[{"award-number":["2015\u201304177"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The titanium\u2013aluminium (6\u2009wt%)\u2013vanadium (4\u2009wt%) (Ti6Al4V) alloy is widely used as an orthopedic and dental implant material due to its high corrosion resistance in such environments. The corrosion resistance is usually determined by means of electrochemical methods, which may not be able to detect other chemical surface reactions. Literature findings report a synergistic effect of the combination of the abundant protein albumin and hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) on the extent of metal release and corrosion of Ti6Al4V. The objectives of this study were to gain further mechanistic insight on the interplay of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and albumin on the metal release process of Ti6Al4V with special focus on (1) kinetics and (2) H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and albumin concentrations. This was accomplished mainly by metal release and surface oxide composition investigations, which confirmed the combined effect of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and albumin on the metal release process, although not detectable by electrochemical open circuit potential measurements. A concentration of 30\u2009m\n                    <jats:italic>M<\/jats:italic>\n                    H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    induced substantial changes in the surface oxide characteristics, an oxide which became thicker and enriched in aluminum. Bovine serum albumin (BSA) seemed to be able to deplete this aluminum content from the outermost surface or at least to delay its surface enrichment. This effect increased with increased BSA concentration, and for time periods longer than 24\u2009h. This study hence suggests that short\u2010term (accelerated) corrosion resistance measurements are not sufficient to predict potential health effects of Ti6Al4V alloys since also chemical dissolution mechanisms play a large role for metal release, possibly in a synergistic way. \u00a9 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 855\u2013867, 2019.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.34182","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T14:15:10Z","timestamp":1534169710000},"page":"858-867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Mechanistic insight on the combined effect of albumin and hydrogen peroxide on surface oxide composition and extent of metal release from Ti6Al4V"],"prefix":"10.1002","volume":"107","author":[{"given":"Yolanda S.","family":"Hedberg","sequence":"first","affiliation":[{"name":"Department of Chemistry, Division of Surface and Corrosion Science KTH Royal Institute of Technology  Drottning Kristinas v\u00e4g 51, SE\u201010044 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"\u017dnidar\u0161i\u010d","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Division of Surface and Corrosion Science KTH Royal Institute of Technology  Drottning Kristinas v\u00e4g 51, SE\u201010044 Stockholm Sweden"},{"name":"Faculty of Chemistry and Chemical Technology University of Ljubljana  Ve\u010dna pot 113, SI\u20101000 Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"Herting","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Division of Surface and Corrosion Science KTH Royal Institute of Technology  Drottning Kristinas v\u00e4g 51, SE\u201010044 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Milo\u0161ev","sequence":"additional","affiliation":[{"name":"Department of Physical and Organic Chemistry Jo\u017eef Stefan Institute  Jamova c. 39, SI\u20101000 Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Odnevall Wallinder","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Division of Surface and Corrosion Science KTH Royal Institute of Technology  Drottning Kristinas v\u00e4g 51, SE\u201010044 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mser.2014.10.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-59453-2.00057-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408444.2014.934439"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007067011338"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00931.x"},{"issue":"3","key":"e_1_2_7_7_1","first-page":"178","article-title":"Allergy to metals as a cause of orthopedic implant failure","volume":"19","author":"Kr\u0119cisz B","year":"2006","journal-title":"Int J Occup Med Env"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02084.x"},{"key":"e_1_2_7_9_1","volume-title":"Metal Allergy\u2014From Dermatitis to Implant and Device Failure","author":"JP Thyssen","year":"2018"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1116\/1.4934628"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.07.046"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21332-x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.9939"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-007-0295-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.5006\/2563"},{"key":"e_1_2_7_16_1","article-title":"Mechanical, chemical and biological damage modes within head\u2010neck tapers of CoCrMo and Ti6Al4V contemporary hip replacements","author":"Hall DJ","year":"2017","journal-title":"J Biomed Mater Res B"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60065-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2005.0086"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108059"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33793"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/la901577j"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)80083-X"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-013-4859-8"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.03.022"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.27.117"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820280115"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9797(89)90117-3"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(89)90019-7"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2800527"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9797(78)90101-7"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0922-338X(95)98168-K"},{"key":"e_1_2_7_32_1","first-page":"181","article-title":"Modeling the dynamics of protein adsorption to surfaces","author":"Nadarajah A","year":"1995","journal-title":"Prot Interfaces II Am Chem Soc"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2014.06.066"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2009.09.069"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199805)40:2<244::AID-JBM9>3.0.CO;2-L"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199603)30:3<393::AID-JBM14>3.0.CO;2-L"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(01)00134-X"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.01.064"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.02.005"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198870030-00005"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.34182","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.34182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T17:00:34Z","timestamp":1694710834000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.34182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,13]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1002\/jbm.b.34182"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.34182","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,13]]},"assertion":[{"value":"2018-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}