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A collagen\/\u03b2\u2010TCP conduit was prepared and applied to a facial nerve gap in a mini\u2010swine model. Functional recovery and axonal regeneration were further evaluated by electrophysiological and histological examinations at 3 months after surgery. Furthermore, the global transcriptomic profiles of regenerated and normal tissues were analyzed by gene microarray to identify the differentially expressed genes at day three and seven, postoperatively. Subsequently, associated biological processes were analyzed by gene ontology (GO) enrichment analysis. The electrophysiological examination and morphological analysis revealed that significant nerve regeneration effects were achieved in the Col\/\u03b2\u2010TCP group (<jats:italic>p<\/jats:italic> &lt; 0.05). Transcriptional analysis revealed that at day three post\u2010surgery, the majority of overexpressed genes were associated with inflammatory, immune and stimuli response, accompanied by angiogenesis, while at day seven, the majority of overexpressed genes were associated with cell, tissue and organ regeneration and development, synaptic transmission, neurogenesis, and neuronal differentiation, as well as the WNT, MAPK\/ERK, and JAK\/STAT signaling pathways. In conclusion, the present results suggest that collagen\/\u03b2\u2010TCP NGCs provide a promising tubular micro\u2010environment for nerve regeneration. \u00a9 2018 Wiley Periodicals, Inc. 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