{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:40:42Z","timestamp":1762252842120},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T00:00:00Z","timestamp":1539302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Short Bowel Survivor and Friends charity","award":["1149354"],"award-info":[{"award-number":["1149354"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intestinal circumferential expansion is essential for bowel lengthening in patients with Short Bowel Syndrome. We hypothesized use of an endoluminal osmotic hydrogel expander (EOHE) as a novel approach for intestinal expansion.<\/jats:p><jats:p>An EOHE was introduced into an isolated intestinal segment of New Zealand rabbits, with a similar segment created as a control. After 4weeks, the segments were retrieved for analysis. Weight, inflammatory markers and fluoroscopy data was recorded weekly. EOHE allowed successful expansion of intestinal segments from 4.68 \u00b1 0.35 to 9.79 \u00b1 0.35 cm (<jats:italic>p<\/jats:italic> = 0.01). Increase in intestinal length was 167.8 \u00b1 35.21% in segments with EOHE vs. 23.03 \u00b1 4.2% in the control group (<jats:italic>p<\/jats:italic> &lt; 0.01). A significant intestinal dilatation (214.4 \u00b1 1.58 vs. 34.59 \u00b1 1.23%, <jats:italic>p<\/jats:italic> &lt; 0.01) was demonstrated. Hematoxylin and eosin stain revealed conservation of intestinal architecture with muscle hypertrophy and flattening of the epithelium possibly due to compression. No reduction of rabbit weight, inflammatory markers or liver damage was described. EOHE appears to produce safe intestinal expansion, achieving increased length and dilatation suitable for lengthening procedure. This approach may allow development of similar techniques to expand bowel in short bowel patients. \u00a9 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1304\u20131309, 2019.<\/jats:p>","DOI":"10.1002\/jbm.b.34224","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T17:44:08Z","timestamp":1539366248000},"page":"1304-1309","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Expanding intestinal segment using osmotic hydrogel: An <i>in vivo<\/i> study"],"prefix":"10.1002","volume":"107","author":[{"given":"Riccardo","family":"Coletta","sequence":"first","affiliation":[{"name":"Institute of Human Development Faculty of Medical and Human Sciences, University of Manchester  Manchester UK"},{"name":"Paediatric Autologous Bowel Reconstruction and Rehabilitation Unit, Department of Paediatric Surgery Royal Manchester Children's Hospital  Manchester UK"},{"name":"Department of Pediatric Surgery Meyer Children's Hospital, University of Florence  Florence 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