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Degradable tracheal stent placement will avoid complications of stent removal and restenosis. Widespread reports exist on degradable magnesium alloys success for orthopedic and cardiovascular applications but none to date for intra tracheal use. This research explores the use of pure Mg, AZ31, and Mg\u20103Y alloys for degradable tracheal stent assessment. <jats:italic>In vitro<\/jats:italic> evaluation of magnesium, prototype stents in a bioreactor simulate the airway environment and corrosion. Micro\u2010CT imaging and biocompatibility evaluation helped assess the 24\u2010week degradation of intraluminal alloy stents following implantation in a rat tracheal <jats:italic>in vivo<\/jats:italic> bypass model. Histological analysis indicate tissue response of the harvested stented trachea segments after each time point. Corrosion studies for each alloy indicate significant differences between the simulated and control <jats:italic>in vitro<\/jats:italic> conditions. AZ31 exhibited the lowest volume loss of 6.8% in saline, while pure Mg displayed the lowest volume loss of 4.6% in simulated airway fluid (SAF), both at 1\u2010week time points. Significant differences in percentage of total volume lost after 6 months were determined between the alloys over time. MgY alloy displayed the slowest corrosion losing only 15.1% volume after 24 weeks of immersion. Additionally, <jats:italic>in vitro<\/jats:italic> magnesium alloy corrosion was not significantly different from the percentage of total volume lost <jats:italic>in vivo<\/jats:italic> at 1\u2010week time point. The study demonstrates promise of magnesium alloys for intraluminal tracheal stent application albeit viability of a clinically translatable model warrants further studies. \u00a9 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1844\u20131853, 2019.<\/jats:p>","DOI":"10.1002\/jbm.b.34277","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T18:57:16Z","timestamp":1544122636000},"page":"1844-1853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Evaluation of magnesium alloys for use as an intraluminal tracheal for pediatric applications in a rat tracheal bypass model"],"prefix":"10.1002","volume":"107","author":[{"given":"Sarah A.","family":"Luffy","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania 15261"},{"name":"McGowan Institute of Regenerative Medicine University of Pittsburgh  Pittsburgh Pennsylvania 15261"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania 15261"},{"name":"McGowan Institute of Regenerative Medicine University of Pittsburgh  Pittsburgh Pennsylvania 15261"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1227-1249","authenticated-orcid":false,"given":"Prashant N.","family":"Kumta","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania 15261"},{"name":"McGowan Institute of Regenerative Medicine University of Pittsburgh  Pittsburgh Pennsylvania 15261"},{"name":"Department of Mechanical Engineering and Materials Science University of Pittsburgh  Pittsburgh Pennsylvania 15261"},{"name":"Department of Chemical and Petroleum Engineering University of Pittsburgh  Pittsburgh Pennsylvania 15261"},{"name":"Department of Oral Biology, School of Dental Medicine University of Pitsburgh  Pennsylvania 15261"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas W.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania 15261"},{"name":"McGowan Institute of Regenerative Medicine University of Pittsburgh  Pittsburgh Pennsylvania 15261"},{"name":"Department of Cardiothoracic Surgery Children's Hospital of Pittsburgh of UPMC  Pittsburgh Pennsylvania"},{"name":"ACell, Inc.  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