{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T01:00:14Z","timestamp":1784595614903,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T00:00:00Z","timestamp":1547683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An ideal stent to treat cerebral aneurysms should have an antithrombotic effect on the inner stent blood\u2010facing side and a tissue organization effect on the outer aneurysmal side of the stent. The objective of this study is to evaluate the feasibility of a drug containing stent in the in vivo treatment of cerebral aneurysms. Argatroban, an antithrombotic drug, is encapsulated in biodegradable poly (<jats:sc>d,l<\/jats:sc>\u2010lactide\u2010co\u2010glycolide) (PLGA) microspheres for the controlled release with an in vitro study conducted to evaluate the drug release and anticoagulation behavior of released drug. Basic fibroblast growth factor (bFGF), an organization drug, is released from gelatin hydrogels. The stents are coated with gelatin hydrogels incorporating bFGF and PLGA microspheres containing argatroban, and applied to the carotid artery aneurysm of an elastase\u2010induced rabbit model. Most of the aneurysm cavity is occupied by loose connective tissues in the group treated with drug\u2010coated stents, whereas extensive massive hematomas are observed in the group treated with drug\u2010free stents. The occurrence rate of in\u2010stent thrombus is small in the drug\u2010coated stents. The stent incorporating bFGF and PLGA microspheres containing argatroban is an effective device for cerebral aneurysm treatment. \u00a9 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2185\u20132194, 2019.<\/jats:p>","DOI":"10.1002\/jbm.b.34314","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T18:02:45Z","timestamp":1547748165000},"page":"2185-2194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Development of a stent capable of the controlled release of basic fibroblast growth factor and argatroban to treat cerebral aneurysms: In vitro experiment and evaluation in a rabbit aneurysm model"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3049-6919","authenticated-orcid":false,"given":"Daisuke","family":"Arai","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Kyoto University Graduate School of Medicine  Kyoto Japan"},{"name":"Laboratory of Biomaterials, Institution for Frontier Life and Medicine Sciences Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Abekura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehisa","family":"Nishi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Tabata","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials, Institution for Frontier Life and Medicine Sciences Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2421"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13120099"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.12.JNS141259"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4175"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/JNS-07\/07\/0109"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2370"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2012.09.023"},{"issue":"7","key":"e_1_2_10_9_1","first-page":"1410","article-title":"Delivery of human vascular endothelial growth factor with platinum coils enhances wall thickening and coil impregnation in a rat aneurysm model","volume":"22","author":"Abrahams JM","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"issue":"3","key":"e_1_2_10_10_1","first-page":"690","article-title":"Transforming growth factor beta\u2010coated platinum coils for endovascular treatment of aneurysms: an animal study","volume":"49","author":"Gast AN","year":"2001","journal-title":"Neurosurgery"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200110000-00030"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000073595.92557.36"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000195095.66984.24"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/107602960200800304"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00121-0"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.1999.5.127"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.174.2.1740349"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.21.2550"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e3181eb95da"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-013-1150-0"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2014.04.013"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041360321"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbir.1995.1087"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100140317"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00281-1"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.61.256"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-726X(199904)46:4<503::AID-CCD25>3.0.CO;2-3"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31914"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.06.057"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym3031377"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(03)00364-X"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.186429"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.05.060"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069103"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.34314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.34314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.b.34314","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.34314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T20:11:05Z","timestamp":1694290265000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.34314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,17]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/jbm.b.34314"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.34314","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,17]]},"assertion":[{"value":"2018-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}