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Temozolomide (TMZ) is the chemotherapy drug that is most commonly given orally after surgical resection of these tumors. In this study, the effects of solvents (i.e., dichloromethane and acetonitrile) used for the fabrication of electrosprayed TMZ\u2010loaded poly(lactic\u2010<jats:italic>co<\/jats:italic>\u2010glycolic acid) (PLGA) on drug loading, loading efficiency, drug release kinetics, surface morphology, and particle size were investigated. The results from this study demonstrated that by using a larger volume of a solvent with higher polarity (i.e., acetonitrile) which allows for a higher amount of hydrophilic TMZ to dissolve into the polymer solution, higher drug loading could be achieved. However, the particles fabricated with high amount of acetonitrile, which has a lower vapor pressure, had large pores and a smaller diameter which led to an initial burst release and high cumulative release at the end of the study. An optimal combination of the two solvents is needed to result in particles with a good amount of loading and minimal initial burst release. The electrosprayed microparticles were able to illicit a cytotoxic response in U\u201087 MG glioblastoma cells at a lower concentration of drug compared to the free drug. This work indicated that electrospraying is a promising method for the fabrication of TMZ\u2010loaded PLGA microparticles for the treatment of GBM and solvent composition can be altered to control drug loading and release kinetics. \u00a9 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2317\u20132324, 2019.<\/jats:p>","DOI":"10.1002\/jbm.b.34324","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T10:00:47Z","timestamp":1550224847000},"page":"2317-2324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of solvent used for fabrication on drug loading and release kinetics of electrosprayed temozolomide\u2010loaded PLGA microparticles for the treatment of glioblastoma"],"prefix":"10.1002","volume":"107","author":[{"given":"Daniel A.","family":"Rodriguez de Anda","sequence":"first","affiliation":[{"name":"Department of Health and Biomedical Sciences University of Texas Rio Grande Valley  One West University Blvd., Brownsville Texas, 78520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nareg","family":"Ohannesian","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy 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