{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:38:23Z","timestamp":1787315903817,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,1,26]],"date-time":"2019-01-26T00:00:00Z","timestamp":1548460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the National Key R&D Program of China","award":["Grant No. 2016YFC1101802, 2016YFC1101804, 2016YFC1"],"award-info":[{"award-number":["Grant No. 2016YFC1101802, 2016YFC1101804, 2016YFC1"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We investigated the effects of magnesium (Mg) on osteogenesis and bone resorption at a porous structure interface. A three\u2010dimensional (3D)\u2010printed porous Ti6Al4V implant coated with Mg was introduced, and polyether\u2010ether\u2010ketone wear particles were added to generate an animal model of implant loosening. We also examined the effects of Mg leach liquor on osteoblast\/osteoclast gene expression, alkaline phosphatase activity, collagen secretion, tartrate\u2010resistant acid phosphatase activity, and bone resorption in vitro. Mg inhibited the early stage of osteoclast differentiation and inhibited bone resorption in vitro and in vivo. However, Mg did not enhance osteogenesis in vitro or in vivo in the porous structures or in peripheral areas around the implants. For implants with porous structures, the Mg coating did not improve the osteogenic ability by itself, but could restrain peri\u2010implant osteolysis, which may make it favorable for use in patients with osteoporosis. Further studies are needed to examine the precise mechanism of Mg\u2010induced anti\u2010osteolysis and the long\u2010term effects of Mg\u2010coated implants in humans. \u00a9 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2388\u20132396, 2019.<\/jats:p>","DOI":"10.1002\/jbm.b.34332","type":"journal-article","created":{"date-parts":[[2019,1,26]],"date-time":"2019-01-26T03:51:13Z","timestamp":1548474673000},"page":"2388-2396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of magnesium coating on bone\u2010implant interfaces with and without polyether\u2010ether\u2010ketone particle interference: A rabbit model based on porous Ti6Al4V implants"],"prefix":"10.1002","volume":"107","author":[{"given":"Zhe","family":"Du","sequence":"first","affiliation":[{"name":"Trauma Center Peking University People's Hospital  Beijing China"},{"name":"Department of Bone and Joint Surgery Renji Hospital, School of Medicine, Shanghai Jiaotong University  Shanghai 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