{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:21:58Z","timestamp":1792182118061,"version":"4.4.0"},"reference-count":60,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T00:00:00Z","timestamp":1550448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32 GM8339"],"award-info":[{"award-number":["T32 GM8339"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The menisci transmit load by increasing the contact area and decreasing peak contact stresses on the articular surfaces. Meniscal lesions are among the most common orthopedic injuries, and resulting meniscectomies are associated with adverse polycaprolactone contact mechanics changes and, ultimately, an increased likelihood of osteoarthritis. Meniscus scaffolds were fabricated by 3D\u2010printing a network of circumferential and radial filaments of resorbable polymer (poly(desaminotyrosyl\u2010tyrosine dodecyl ester dodecanoate)) and infused with collagen\u2010hyaluronan. The scaffold demonstrated an instantaneous compressive modulus (1.66\u2009\u00b1\u20090.44\u2009MPa) comparable to native meniscus (1.52\u2009\u00b1\u20090.59\u2009MPa). The scaffold aggregate modulus (1.33\u2009\u00b1\u20090.51\u2009MPa) was within 2% of the native value (1.31\u2009\u00b1\u20090.36\u2009MPa). In tension, the scaffold displayed a comparable stiffness to native tissue (127.6\u201397.1 N\/mm) and an ultimate load of 33% of the native value. Suture pull\u2010out load of scaffolds (83.1\u2009\u00b1\u200910.0 N) was within 10% of native values (91.5\u2009\u00b1\u200915.4 N). Contact stress analysis demonstrated the scaffold reduced peak contact stress by 60\u201367% and increased contact area by 38%, relative to partial meniscectomy. This is the first meniscal scaffold to match both the axial compressive properties and the circumferential tensile stiffness of the native meniscus. The improvement of joint contact mechanics, relative to partial meniscectomy alone, motivates further investigation using a large animal model. \u00a9 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2457\u20132465, 2019.<\/jats:p>","DOI":"10.1002\/jbm.b.34336","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T13:08:55Z","timestamp":1550495335000},"page":"2457-2465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Biomechanical characterization of a novel collagen\u2010hyaluronan infused 3D\u2010printed polymeric device for partial meniscus replacement"],"prefix":"10.1002","volume":"107","author":[{"given":"Salim A.","family":"Ghodbane","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Rutgers Biomedical and Health Sciences \u2010 Robert Wood Johnson Medical School New Brunswick New Jersey USA"},{"name":"Department of Biomedical Engineering Rutgers, The State University of New Jersey Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay 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