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In the study, we develop a sustained drug releasing system loaded with levofloxacin which is expected to be effective against common pathogens responsible for POE for at least 7 days after single application at the end of surgery. The results of study showed that the sol\u2013gel transition temperature of the levofloxacin\u2010loaded chitosan\u2010gelatin\u2010based solution was ~34\u00b0C. The gelation time of the developed formulation was ~81\u2009s at 34\u00b0C. The results showed that the osmolality of developed hydrogel was 304\u2009mOsm\/L. The\n                    <jats:italic>in vitro<\/jats:italic>\n                    drug release studies revealed that levofloxacin release from the developed hydrogel displayed a sustained\u2010release profile. The long\u2010term antibacterial property of the developed hydrogel has been demonstrated. The biocompatibility of the developed hydrogel was evaluated\n                    <jats:italic>in vitro<\/jats:italic>\n                    . These results suggest that the levofloxacin\u2010containing hydrogel could be applied to ocular surface at the end of ophthalmic surgery, without the risks of intracameral injection of antibiotics. \u00a9 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:8\u201313, 2020.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.34359","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T15:41:22Z","timestamp":1553182882000},"page":"8-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Sustained release of levofloxacin from thermosensitive chitosan\u2010based hydrogel for the treatment of postoperative endophthalmitis"],"prefix":"10.1002","volume":"108","author":[{"given":"Yung\u2010Hsin","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering National Taiwan University of Science and Technology  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Fan","family":"Chang","sequence":"additional","affiliation":[{"name":"National Yang\u2010Ming University School of Medicine  Taipei Taiwan"},{"name":"Department 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