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Conventional encapsulation of cells using hydrogels often needs the polymerization process or relatively complex molding process. In this study, we developed a facile strategy for the in situ fabrication of biodegradable cell\u2010laden starch foams. By utilizing the unique gelatinization property of starch, cell\u2010laden starch foams with tunable architecture were rapidly prepared in a green and biological\u2010friendly process. The bubble size and stiffness of starch foams could be tuned by controlling the content of premixed starch in the cell culture medium. Cells were encapsulated in situ during the foaming process, and the resultant starch foams could be used as building blocks to fabricate three\u2010dimensional tissue construct. The potential application of the cell\u2010laden starch foams in neural tissue engineering was also validated. RSC96 Schwann cells were encapsulated in the starch foams and revealed good viability. Due to the serum\u2010induced degradation of the starch, RSC96 Schwann cells could be released from the starch foams in a controlled manner while remaining high viability. Dorsal root ganglion (DRG) neurons co\u2010cultured with the cell\u2010laden starch foams extended significantly longer neurites compared with neurons cultured in minimum Eagle's medium (664.88\u2009\u00b1\u2009190.39\u2009\u03bcm vs. 311.19\u2009\u00b1\u2009105.25\u2009\u03bcm). DRG neurons retained high viability even after encapsulation in the starch foams for 3\u2009days. This facile strategy of rapidly fabricating cell\u2010laden starch foams can be further extended to construct centimeter\u2010scale micro\u2010tissue for tissue engineering applications. \u00a9 2019 Wiley Periodicals, Inc. 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