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Microtomographic, histomorphometric, and immunolabeling for TRAP\u2010cells analyses were made at 15, 30, and 60\u2009days after surgery. In all treatments, a faster bone formation\/remodeling\/maturation and TRAP\u2010positive cells activity occurred in the osteotomy region of the MSA than in the middle and submucosa regions. In the \u03b2\u2010TCP, the granules were rapidly reabsorbed by TRAP\u2010positive cells and replaced by bone tissue. \u03b2\u2010TCP enabled quick bone regeneration\/remodeling and full bone and marrow restoration until 60\u2009days, but with a significant reduction in MSA volume. In cDBB and sDBB, the quantity of TRAP\u2010positive cells was smaller than in \u03b2\u2010TCP, and these cells were associated with granule surface preparation for osteoblast\u2010mediated bone formation. After 30\u2009days, more than 80% of granule surfaces were surrounded and integrated by bone tissue without signs of degradation, preserving the MSA volume. Overall, the materials tested in a standardized preclinical model led to different bone formation\/remodeling\/maturation within the same repair process influenced by different microenvironments and MGCs\/osteoclasts. \u00a9 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:282\u2013297, 2020.<\/jats:p>","DOI":"10.1002\/jbm.b.34388","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T15:46:31Z","timestamp":1555947991000},"page":"282-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<i>In vitro<\/i>and<i>in vivo<\/i>assessment of CaP materials for bone regenerative therapy. 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