{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:51:48Z","timestamp":1765486308352,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several nerve conduits have been investigated for their potential as alternative sources of autografts for bridging neural gaps. However, autologous nerve transplants remain the most effective for nerve repair. We examined clinically approved nerve conduits containing collagen and polyglycolic acid (PGA\u2010c) combined with collagen\u2010binding basic fibroblast growth factor (bFGF) containing a polycystic kidney disease (PKD) domain and collagen binding domain (CBD) (bFGF\u2010PKD\u2010CBD) in a rat 15\u2010mm sciatic nerve critical\u2010size defect model. The treatment groups were: PGA\u2010c immersed in phosphate\u2010buffered saline (PBS) (PGA\u2010c\/PBS group), bFGF (PGA\u2010c\/bFGF group), or bFGF\u2010PKD\u2010CBD (PGA\u2010c\/bFGF\u2010PKD\u2010CBD group), and no treatment (Defect group). Gait and histological analyses were performed. Four weeks after treatment, the recovery rate of the paw print area was significantly greater in the PGA\u2010c\/bFGFPKD\u2010CBD group than the PGA\u2010c\/PBS and PGA\u2010c\/bFGF groups. Mean intensity of paw prints was significantly greater in the PGA\u2010c\/bFGF\u2010PKD\u2010CBD group than the PGA\u2010c\/PBS and Defect groups. Swing time was significantly greater in the PGA\u2010c\/PBS, PGA\u2010c\/bFGF, and PGA\u2010c\/bFGF\u2010PKD\u2010CBD groups than the Defect group. At 8 weeks, all three parameters were significantly greater in the PGA\u2010c\/PBS, PGA\u2010c\/bFGF, and PGA\u2010c\/bFGF\u2010PKD\u2010CBD groups than the Defect group. Regenerated myelinated fibers were observed in 7\/8 (87.5%) rats in the PGA\u2010c\/bFGF\u2010PKD\u2010CBD group after 8 weeks, and in 1\/8 (12.5%) and 3\/8 (37.5%) rats in the PGA\u2010c\/PBS and PGA\u2010c\/bFGF groups, respectively. PGA\u2010c\/bFGF\u2010PKD\u2010CBD composites may be promising biomaterials for promoting functional recovery of long\u2010distance peripheral nerve defects in clinical practice.<\/jats:p>","DOI":"10.1002\/jbm.b.34391","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T05:39:47Z","timestamp":1556084387000},"page":"326-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Polyglycolic acid\u2010collagen tube combined with collagen\u2010binding basic fibroblast growth factor accelerates gait recovery in a rat sciatic nerve critical\u2010size defect model"],"prefix":"10.1002","volume":"108","author":[{"given":"Hisako","family":"Fujimaki","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Kitasato University School of Medicine  Sagamihara Kanagawa 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