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In order to more closely reflect the anatomical and clinical environments around dental implants, and eventually be able to experimentally address load\u2010management issues, we have developed a system that allows initial stabilization, protection from external forces, and controlled axial loading of implants. Screw\u2010shaped implants were placed on the edentulous ridge in rat maxillae. Three loading regimens were applied to validate the system; <jats:italic>case A<\/jats:italic> no loading (unloaded implant) for 14\u2009days, <jats:italic>case B<\/jats:italic> no loading in the first 7 days followed by 7 days of a single, daily loading session (60\u2009cycles of an axial force of 1.5 N\/cycle), and <jats:italic>case C<\/jats:italic> no loading in the first 7 days followed by 7 days of two such daily loading sessions. Finite element modeling of the peri\u2010implant compressive and tensile strains plus histological and immunohistochemical analyses revealed that in <jats:italic>case B<\/jats:italic> any tissue damage resulting from the applied force (and related interfacial strains) did not per se disturb bone healing, however, in <jats:italic>case C<\/jats:italic>, the accumulation of damage resulting from the doubling of loading sessions severely disrupted the process. These proof\u2010of\u2010principle results validate the applicability of our system for controlled loading, and provide new evidence on the importance of the number of load cycles applied on healing of maxillary bone.<\/jats:p>","DOI":"10.1002\/jbm.b.34449","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T06:35:46Z","timestamp":1564641346000},"page":"965-975","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["System for application of controlled forces on dental implants in rat maxillae: Influence of the number of load cycles on bone healing"],"prefix":"10.1002","volume":"108","author":[{"given":"Renan","family":"de Barros e Lima Bueno","sequence":"first","affiliation":[{"name":"Laboratory for the Study of Calcified Tissues and Biomaterials, Faculty of Dental Medicine Universit\u00e9 de Montr\u00e9al  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana P.","family":"Dias","sequence":"additional","affiliation":[{"name":"Laboratory for the Study of Calcified Tissues and Biomaterials, Faculty of Dental Medicine Universit\u00e9 de Montr\u00e9al  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia J.","family":"Ponce","sequence":"additional","affiliation":[{"name":"Laboratory for the Study of Calcified Tissues and Biomaterials, Faculty of Dental Medicine Universit\u00e9 de Montr\u00e9al  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B.","family":"Brunski","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medicine, Stanford University  Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Nanci","sequence":"additional","affiliation":[{"name":"Laboratory for the Study of Calcified Tissues and Biomaterials, Faculty of Dental Medicine Universit\u00e9 de Montr\u00e9al  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510378427"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"76","article-title":"Comparative bone anatomy of commonly used laboratory animals: Implications for drug discovery","volume":"61","author":"Bagi C. 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