{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:08:40Z","timestamp":1780513720919,"version":"3.54.1"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Evaluation of mucosal permeation of stigmasterol from the glutaraldehyde cross linked chitosan microspheres at increasing experimental temperatures was performed. The activation energy of permeation, partition, and diffusion were estimated to understand the permeation kinetic with respect to the temperature. The formulation depicting least activation energy possessed the increased permeation thresholds of drug at the site of application. The encapsulation efficacy and mucoadhesive strength were found to be directly proportional to the polymer\u2010emulsifier ratio. Decreased intensity in crystallography directed the molecular dispersion of microencapsulated drug. The depleted enthalpic phase transition in thermogram affirmed the stigmasterol encapsulation. The sphericity and the size of microspheres were determined by scanning electron photo micrograph. The in vivo quantification of oral<jats:italic>Candida<\/jats:italic>infection with different statistical approach and histopathological observation of infected tongue of mice on treatment with the stigmasterol encapsulated microspheres showed significant anti oral candidiasis activity by reduction of fungal colony count and recovery of papillae, reorganization of basal cell layer and newly formed papillae during 21\u201328\u2009days of treatment.<\/jats:p>","DOI":"10.1002\/jbm.b.34510","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T13:46:30Z","timestamp":1573652790000},"page":"1636-1654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Temperature\u2010dependent mucosal permeation kinetics of stigmasterol microspheres: In vivo mice model antioral candidiasis study"],"prefix":"10.1002","volume":"108","author":[{"given":"Partha","family":"Niyogi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmaceutical Sciences Siksha \u2018O\u2019 Anusandhan Deemed to be University Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snigdha","family":"Pattnaik","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmaceutical Sciences Siksha \u2018O\u2019 Anusandhan Deemed to be University Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laxmidhar","family":"Maharana","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Sciences Siksha \u2018O\u2019 Anusandhan Deemed to be University Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajaram","family":"Mohapatra","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmaceutical Sciences Siksha \u2018O\u2019 Anusandhan Deemed to be University Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saikat","family":"Haldar","sequence":"additional","affiliation":[{"name":"Medicinal, Aromatic and Economic Plants Group, Biological Sciences and Technology Division CSIR\u2010North East Institute of Science and Technology Jorhat Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.farmac.2003.11.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-780950-2.50013-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-3659(96)01369-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.12.046"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-011-1154-4"},{"issue":"1","key":"e_1_2_7_7_1","first-page":"1419","article-title":"Chronopharmaceutical release of theophylline from pulsatile capsular device based on programmable erodible plug: Influence of various poylmers and plug position","volume":"3","author":"Bhat A.","year":"2011","journal-title":"International Journal of Pharmacy and Technology"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(91)90110-X"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2014.01.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/10731199109117852"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-7388(00)00314-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652040500435436"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.33786\/JCPR.2012.v02i02.006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1461-5347(98)00059-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.09.078"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-893997-92-9.50013-X"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2010.01198.x"},{"issue":"3","key":"e_1_2_7_18_1","first-page":"161","article-title":"Oral candidiasis in children with immune suppression: Clinical appearance and therapeutic considerations","volume":"66","author":"Flaitz C. M.","year":"1999","journal-title":"ASDC Journal of Dentistry for Children"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1984-82502013000300015"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2011.02.001"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(97)00096-3"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.200810071"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600770105"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567201052772906"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(01)02237-5"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600521210"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie50260a018"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(95)99639-4"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1354-523X.2003.00978.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-009-0673-4"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-409X(93)90027-2"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357991773168"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2009.00541.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(83)90064-9"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-011-9624-z"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600530722"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.60.7.0004"},{"issue":"4","key":"e_1_2_7_38_1","first-page":"510","article-title":"Phytochemical studies of Strychnos potatorum Lf\u2010A medicinal plant","volume":"4","author":"Mallikharjuna P. B.","year":"2007","journal-title":"Journal of Chemistry"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.4.1008-1013.2001"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2014.09.012"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.24.470"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0104-66322005000300004"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2008.12.002"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(82)90043-6"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2011.01.030"},{"issue":"8","key":"e_1_2_7_46_1","first-page":"398","article-title":"Formulation, evaluation and solid\u2010state thermographic characterization of CFC free beclometasone dipropionate pressurized metered dose inhalation","volume":"6","author":"Pattnaik S.","year":"2014","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(97)00358-X"},{"issue":"4","key":"e_1_2_7_48_1","first-page":"206","article-title":"Formulation and in vitro evaluation of floating microspheres of dextromethorphan hydrobromide","volume":"6","author":"Perumandla P. K.","year":"2014","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986606775974366"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.56.8.1942-1949.1988"},{"issue":"1","key":"e_1_2_7_51_1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.25004\/IJPSDR.2009.010109","article-title":"Effect of method of preparation on chitosan microspheres of mefenamic acid","volume":"1","author":"Roy S.","year":"2009","journal-title":"International Journal of Pharmaceutical Sciences and Drug Research"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(84)90090-5"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.2.398-429.2001"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"issue":"2","key":"e_1_2_7_55_1","first-page":"119","article-title":"Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC","volume":"19","author":"Shoaib M. H.","year":"2006","journal-title":"Pakistan Journal of Pharmaceutical Sciences"},{"key":"e_1_2_7_56_1","unstructured":"Sinko P. J. Solubility and distribution phenomena. Martin's Phys Pharmacy Pharmaceutical Science. 2006 Lippincott Williams & Wilkins a Wolters Kluwer business China;2011. pp182\u2013196."},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.011"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2017.12.021"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2003.tb03403.x"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.33.1983"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242004000300005"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2014.11.010"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA20675A"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.8.4588-4595.2005"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.34510","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.b.34510","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.34510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T21:20:28Z","timestamp":1722028828000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.34510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,13]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/jbm.b.34510"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.34510","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,13]]},"assertion":[{"value":"2019-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}