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Resveratrol has been shown to reduce oxidative stress in dysfunctional endothelial cells, and stimulate arterial healing. Resveratrol treatments, however, are limited by low water solubility, such that a localized delivery to the site of arterial narrowing via a coated stent presents a promising strategy for improving stent outcomes. Our attachment strategy utilizes zirconium vapor deposition to lay down a thin layer of zirconium oxide with labile hydrocarbon groups at the surface. Resveratrol can displace these hydrocarbons in aprotic solvent to afford a covalently attached layer of resveratrol. We evaluated the release of resveratrol under a range of pH levels, including physiological conditions (pH = 7.4 and 37\u2009\u00b0C). Furthermore, we established that endothelial cells grown on a resveratrol\u2010bound surface release elevated nitric oxide levels compared to controls, a key endothelial signaling molecule responsible for arterial health. These results are promising toward the development of a resveratrol\u2010coated bare\u2010metal stent to improve patient outcomes.<\/jats:p>","DOI":"10.1002\/jbm.b.34568","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T12:20:11Z","timestamp":1580300411000},"page":"2344-2353","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Covalent attachment of resveratrol to stainless steel toward the development of a resveratrol\u2010releasing bare\u2010metal stent"],"prefix":"10.1002","volume":"108","author":[{"given":"Hannah N.","family":"Creasey","sequence":"first","affiliation":[{"name":"Department of Chemistry Lewis &amp; Clark College  Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth Z.","family":"Brandel","sequence":"additional","affiliation":[{"name":"Department of Chemistry Lewis &amp; Clark College  Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Chemistry Lewis &amp; Clark College  Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan J.","family":"Bashore","sequence":"additional","affiliation":[{"name":"Department of Chemistry Lewis &amp; Clark College  Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casey M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Chemistry Lewis &amp; Clark College  Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34144"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000558"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2016.1230017"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061381"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-0366"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/am9004946"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja810075c"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3tb20565g"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000211764.52012.e3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31894"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.01.008"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/63794"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/la9709507"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb16069.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0000000000000178"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1251\/bpo55"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/KEM.309-311.1199"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2013.09.012"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114516001884"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016112798829760"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000029925.18593.5C"},{"key":"e_1_2_6_23_1","unstructured":"World Health Organization World Health Statistics. 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