{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:39:47Z","timestamp":1765805987203},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T00:00:00Z","timestamp":1593302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/K040375\/1"],"award-info":[{"award-number":["EP\/K040375\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The good biocompatibility and corrosion resistance of the bulk CoCrMo alloy has resulted in it being used in the manufacture of implants and load bearing medical devices. These devices, however, can release wear and corrosion products which differ from the composition of the bulk CoCrMo alloy. The physicochemical characteristics of the particles and the associated in vivo reactivity are dictated by the wear mechanisms and electrochemical conditions at the sites of material loss. Debris released from CoCrMo hip bearings, taper junctions, or cement\u2013stem interfaces can, therefore, have different chemical and morphological characteristics, which provide them with different in vivo toxicities. Here, we propose to assess and compare the characteristics of the particles released in vivo from CoCrMo tapers and cement\u2013stem interfaces which have received less attention compared to debris originating from the hip bearings. The study uses state\u2010of\u2010art characterization techniques to provide a detailed understanding of the size, morphology, composition, and chemistry of the particles liberated from the wear and corrosion flakes from revised hip replacements, with an enzymatic treatment. The phase analyses identified Cr<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> nanoparticles released from tapers and cement\u2013stem interfaces, whose composition did not vary with origin or particle morphology. The size distributions showed significantly smaller particles were released from the stems, compared to the particles originating from the corresponding tapers. The investigation demonstrates that the tribocorrosive processes occurring at the taper and stem interfaces both result in Cr<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> nanoparticle formation.<\/jats:p>","DOI":"10.1002\/jbm.b.34667","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T05:20:31Z","timestamp":1593408031000},"page":"3311-3322","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A comparative study on the physicochemical characteristics of nanoparticles released in vivo from <scp>CoCrMo<\/scp> tapers and cement\u2013stem interfaces of total hip replacements"],"prefix":"10.1002","volume":"108","author":[{"given":"Alina M.","family":"Crainic","sequence":"first","affiliation":[{"name":"National Centre for Advanced Tribology at Southampton (nCATS) University of Southampton  Southampton 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