{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:41:35Z","timestamp":1780526495900,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008789","name":"Department of Science and Technology, Government of West Bengal","doi-asserted-by":"publisher","award":["VJR\u20102017\u2010000034"],"award-info":[{"award-number":["VJR\u20102017\u2010000034"]}],"id":[{"id":"10.13039\/501100008789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report on the fabrication of a microneedle\u2010based electrochemical biosensor for use in transdermal biosensing, which includes a screen\u2010printed electrode containing a Prussian blue\u2010gold nanohybrid as the working electrode. The Prussian blue gold nanohybrid is made from polyethylenime (PEI)\u2010 mediated simultaneous synthesis of Prussian blue (PBNP) and gold nanoparticles (AuNP), which forms a PBNP\u2010AuNP nanohybrid with a remarkable change in the Prussian blue character. PEI\u2010protected polycrystalline PBNPs can be synthesized in acidic media from the single precursor potassium ferricyanide [K<jats:sub>3<\/jats:sub>Fe(CN)<jats:sub>6<\/jats:sub>] at 60\u00b0C. Since PEI also enables the controlled formation of gold nanoparticles (AuNPs) in the presence of formaldehyde, nanohybrids containing PBNPs and AuNPs may be prepared. Two different methods of PEI mediated synthesis of AuNP in the presence of PBNP were considered. In Method 1, AuNP and PBNP were made independently and mixed together in an appropriate ratio. In Method 2, PBNPs were made first, followed by PEI\u2010 and formaldehyde\u2010mediated reduction of gold cations in the presence of PBNP. PBNP\u2010AuNPs display a remarkable change in Prussian blue behavior such that the absorption maxima of PBNP\u2010AuNPs made through Method 1 tend to increase at 670\u2009nm as a function of gold concentration as compared with the control; the reverse was observed when PBNP\u2010AuNPs were made through Method 2. As made PBNPs and PBNP\u2010AuNPs made through Method 1 display excellent catalytic activity toward both reduction and oxidation of hydrogen peroxide based on peroxidase mimetic activity. In addition, the as\u2010synthesized PBNPs displayed superparamagnetic behavior that can be manipulated in the presence of AuNPs. The results from peroxidase mimetic activity, chemiluminescence, cyclic voltammetry, and amperometry showed suitable analytical performance of the as\u2010made PBNP\u2010AuNP nanohybrid for biomedical applications.<\/jats:p>","DOI":"10.1002\/jbm.b.34678","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T06:06:30Z","timestamp":1594965990000},"page":"33-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Microneedle\u2010based transdermal electrochemical biosensors based on Prussian blue\u2010gold nanohybrid modified screen\u2010printed electrodes"],"prefix":"10.1002","volume":"109","author":[{"given":"Prem C.","family":"Pandey","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology (BHU)  Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govind","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics King George Medical College  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J.","family":"Narayan","sequence":"additional","affiliation":[{"name":"Joint Department of Biomedical Engineering University of North Carolina and North Carolina State University  Raleigh North Carolina 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