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We prepared perfused decellularized gastric matrix (PDGM) and analyzed its components, spatial structure, biomechanics, cytotoxicity, and histocompatibility to validate its efficacy in the repair of gastric perforation. PDGM retained large amounts of gastric extracellular matrix, while residual glandular cells and muscle fibers were not found. The spatial structure of the tissue was well preserved, while the DNA and glycosaminoglycan contents were significantly decreased compared with normal gastric tissue (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). There was no obvious deformation of the spatial structure and tissue elasticity of PDGM after sterilization by Cobalt\u201060 irradiation. The PDGM had good histocompatibility. PDGM was then used to repair a rat gastric perforation model. Radiography of the upper gastrointestinal tract at 24\u2009hr postoperatively revealed no contrast agent leakage. There was evidence of early fibroblast proliferation, which was complicated by capillary regeneration. The hyperplastic gastric gland was slightly disarranged after repair. Defects of the muscular layer also healed a little with the regeneration process. PDGM is a nontoxic biocompatible biological mesh that may be useful for repairing relatively large gastric defects.<\/jats:p>","DOI":"10.1002\/jbm.b.34713","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T03:08:10Z","timestamp":1598411290000},"page":"451-462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Decellularized gastric matrix as a mesh for gastric perforation repair"],"prefix":"10.1002","volume":"109","author":[{"given":"Liang","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery Nantong University Affiliated Hospital  Nantong Jiangsu China"},{"name":"Department of Burns and Plastic Surgery Nantong Third People's Hospital, Nantong University  Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Lin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Nantong University Affiliated Hospital  Nantong Jiangsu China"},{"name":"Research Center of Clinical Medicine Nantong University Affiliated Hospital  Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Nantong University Affiliated Hospital  Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Nantong University Affiliated Hospital  Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Bing","family":"Guo","sequence":"additional","affiliation":[{"name":"Research Center of Clinical Medicine Nantong University Affiliated Hospital  Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology Nantong University Affiliated Hospital  Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Nantong University Affiliated Hospital  Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin\u2010Sheng","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Nantong University Affiliated Hospital  Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0137-7331","authenticated-orcid":false,"given":"Wan\u2010Jiang","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Nantong University Affiliated Hospital  Nantong Jiangsu China"},{"name":"Research Center of Clinical Medicine Nantong University Affiliated Hospital  Nantong Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"issue":"5","key":"e_1_2_9_2_1","first-page":"547","article-title":"Gastric ulcer and duodenal ulcer (excluding Zollinger\u2010Ellison syndrome). 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