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This study evaluated the outcomes of kidney transplants after cold perfusion and storage with a HPG\u2010based preservation solution (HPGS) in a pig model of kidney autotransplantation. The left kidneys of farm pigs (weighing 35\u201345\u2009kg) were perfused with and stored in either cold HPGS or standard UW solution (UWS), followed by transplantation to the right side after right nephrectomy. The survival and function of transplants were determined by the urine output, and serum creatinine (SCr) and blood urea nitrogen (BUN) of recipients. Transplant injury was examined by histological analysis. Here, we showed that there was no significant difference between HPGS and UWS in the prevention of tissue edema, but HPGS was more effective than UWS for initial blood washout of kidney perfusion and for the prevention of cold ischemia injury during cold storage. After autotransplantation, the kidneys preserved with HPGS (HPG group) had better functional recovery than those with UWS (UW group), indicated by significantly more urine output and lower levels of SCr and BUN. The survived grafts in HPG group had less tissue damage than those in UW group. In conclusion, as compared to the UWS the HPGS has less negative impact on kidney cold ischemia during cold storage, resulting in improving immediate functional recovery after transplantation, suggesting that HPG is a promising colloid for donor kidney preservation.<\/jats:p>","DOI":"10.1002\/jbm.b.34750","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T08:51:58Z","timestamp":1603529518000},"page":"853-863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of hyperbranched polyglycerol for cold perfusion and storage of donor kidneys in a pig model of kidney autotransplantation"],"prefix":"10.1002","volume":"109","author":[{"given":"Shadan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology The General Hospital of Western Theater Command  Chengdu China"},{"name":"Department of Urologic Sciences University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongli","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urologic Sciences University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Urology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology The General Hospital of Western Theater Command  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youguang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Urology The General Hospital of Western Theater Command  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Urology The General Hospital of Western Theater Command  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Urology The General Hospital of Western Theater Command  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of General Surgery The General Hospital of Western Theater Command  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology The General Hospital of Western Theater Command  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiunong","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Urologic Sciences University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Cafeeva","sequence":"additional","affiliation":[{"name":"Centre for Blood Research, and the Department of Pathology and Laboratory Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald E.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Centre for Blood Research, and the Department of Pathology and Laboratory Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Chemistry University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher Y. 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