{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:39:59Z","timestamp":1785901199674,"version":"3.56.0"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polyhydroxyalkanoates (PHAs), also known as bacterial polyesters, are considered novel polymers for fabricating biomedical products, such as sutures and hernia meshes, because of their biocompatibility and slow biodegradability. Poly\u20104\u2010hydroxybutyrate (P4HB) is a commonly used PHA that was explored in this study as an absorbable biomaterial for several medical applications, including controlled drug delivery. Currently, P4HB is melt spun and drawn into filaments at high processing temperatures (~200\u00b0C), precluding the incorporation of thermally sensitive drugs within the polymer during melt spinning. Post\u2010spinning drug incorporation can potentially cause nonuniform drug absorption that leads to an uneven release profile. This raises the need for a low temperature spinning process for these polymers. Until now, there has been no defined procedure to produce P4HB fibers through a low temperature solution spinning process. This study focuses on determining suitable wet spinning conditions to form continuous P4HB fibers. After several preliminary tests, it was found that a chloroform\u2010based spin dope with 10\u201315% polymer concentration facilitated the extrusion of continuous stretchable fibers into a coagulation bath containing reagent alcohol. Subsequently, several P4HB fibers were spun with various spin dope concentrations, coagulation bath temperatures, and spin draw ratios to assess their effect on fiber structure and properties.<\/jats:p>","DOI":"10.1002\/jbm.b.34763","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T07:04:20Z","timestamp":1606374260000},"page":"982-989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effect of wet spinning conditions on the structure and properties of poly\u20104\u2010hydroxybutyrate fibers"],"prefix":"10.1002","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7218-6241","authenticated-orcid":false,"given":"Bhavya","family":"Singhi","sequence":"first","affiliation":[{"name":"Wilson College of Textiles North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ericka N.","family":"Ford","sequence":"additional","affiliation":[{"name":"Wilson College of Textiles North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin W.","family":"King","sequence":"additional","affiliation":[{"name":"Wilson College of Textiles North Carolina State University  Raleigh North Carolina USA"},{"name":"College of Textiles Donghua University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"GalateaSurgical.History of P4HB biopolymer.https:\/\/www.galateasurgical.com\/surgical-scaffolds\/history\/. 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US 20120150285A1 June 14 2012."},{"key":"e_1_2_8_10_1","unstructured":"AgrawalAK National programme on technology enhanced learning (NPTEL).2013;https:\/\/nptel.ac.in\/courses\/116102010\/. Accessed August 27 2018."},{"key":"e_1_2_8_11_1","unstructured":"RizzoP.Polymer Technology Group.http:\/\/www.polymertechnology.it\/bacheca\/NanocompositeForm\/page5\/page5.html. Accessed April 28 2019."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1533\/9780857099174.2.174"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780203501702.ch4"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1103\/RevModPhys.81.1287"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.34763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.b.34763","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.34763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:33:38Z","timestamp":1693614818000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.34763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,25]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/jbm.b.34763"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.34763","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,25]]},"assertion":[{"value":"2020-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}