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In this research, LaVO<jats:sub>4<\/jats:sub>:Eu<jats:sup>3+<\/jats:sup> was synthesized, the luminescent nanocrystal was coated by surface polymerization of levodopa in the presence of Paclitaxel (PTX), and then NL2 peptide was coupled on the surface of polymer\u2010coated luminescent nanoparticles. Next, the capability of the modified drug was examined by in vitro and in vivo experiments. MTT assay on SK\u2010BR\u20103 cell line (as breast cancer cells) and fluorescent microscopy results indicate that this modification decreases significantly drug toxicity and increases its selectivity. In addition, in vivo experiments confirm more capability of the NL2\u2010functionalized nanocomposite for reducing tumor size, drug distribution in the body, and more aggregation of PTX in tumor tissue. Overall, it is concluded that tumor imaging is possible using luminescent LaVO<jats:sub>4<\/jats:sub>:Eu<jats:sup>3+<\/jats:sup> core and NL2 peptide increases significantly the specificity of PTX in combination with a functionalized luminescent polymeric carrier.<\/jats:p>","DOI":"10.1002\/jbm.b.34816","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T02:32:29Z","timestamp":1613874749000},"page":"1578-1587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Targeted delivery of paclitaxel by <scp>NL2<\/scp> peptide\u2010functionalized on core\u2010shell <scp>LaVO4<\/scp>: Eu3@ poly (levodopa) luminescent nanoparticles"],"prefix":"10.1002","volume":"109","author":[{"given":"Hamid","family":"Hashemi\u2010Moghaddam","sequence":"first","affiliation":[{"name":"Department of Chemistry, Damghan Branch Islamic Azad University  Damghan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansore","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Damghan Branch Islamic Azad University  Damghan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behrooz","family":"Johari","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, School of Medicine Zanjan University of Medical Sciences  Zanjan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Madanchi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Medicine Semnan University of Medical Sciences  Semnan Iran"},{"name":"Drug Design and Bioinformatics Unit, Department of Medical Biotechnology Biotechnology Research Center, Pasteur Institute of Iran  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bio.3520"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10971-018-4897-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8084659"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.12.002"},{"key":"e_1_2_9_6_1","first-page":"1088207","article-title":"Multiparametric luminescence lifetime imaging: a new diagnostic tool to follow up bioenergetic alterations during PDT","volume":"10882","author":"R\u00fcck A","year":"2019","journal-title":"Int Soc Opt Photonics"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.12.010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b01160"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic302297u"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/784097"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1142\/9781783269617_0002","article-title":"Lanthanide\u2010doped Upconverting Nanoparticles for Biological Applications","volume":"1","author":"Zhang Y","year":"2016","journal-title":"Perspect Micro Nanotechnol Biomed Appl: World Sci"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2016.09.053"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00917-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201804510"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.03.025"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.porgcoat.2017.10.007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2018.09.019"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.09.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reactfunctpolym.2017.10.025"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","unstructured":"KeservaniRK SharmaAK JarouliyaU.Protein and peptide in drug targeting and its therapeutic approach. 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