{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:29:57Z","timestamp":1790418597291,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T00:00:00Z","timestamp":1616284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mandibular osteomyelitis (OM) is a challenging disease. Our objective was to assess a new OM model in rabbits induced by arsenic trioxide and to assess the efficacy of local treatment of OM using injectable gentamicin\u2010collagen hydrogels (GNT\u2010COLL). OM was induced unilaterally by controlled confinement of arsenic trioxide paste to the root canal of lower incisors of rabbits, while OM progression was characterized for 16\u2009weeks. On the other hand, two injectable COLL hydrogels functionalized with GNT were prepared and characterized for physicochemical properties; a simple GNT\u2010COLL and a nanohydroxyapatite (nHA)\u2010 loaded hydrogel (GNT\u2010COLL\/nHA). The two hydrogels were evaluated to treat OM model, while a multidose intramuscular GNT solution served as positive control. Outcomes were assessed by standard methods at 4 and 12\u2009weeks post\u2010surgery. The clinical, radiographical, and histopathological findings provided evidence for the validity of the arsenic\u2010induced OM. The results demonstrated that a single intra\u2010lesional injection of the two hydrogels was more suppressive to OM compared to multidose systemic GNT. The composite GNT\u2010COLL\/nHA hydrogel proved to induce early preservation of alveolar bone (ridge) length and higher amount of bone area\\total area at 4\u2009weeks (40.53%\u2009\u00b1\u20092.34) followed by GNT\u2010COLL (32.21%\u2009\u00b1\u20090.72). On the other hand, the positive control group revealed the least ridge length and bone area\\total area (26.22%\u2009\u00b1\u20091.32) at 4\u2009weeks. Both hydrogels successfully arrested OM with no signs of recurrence for up to 12\u2009weeks. Therefore, results support the greater advantages of the composite hydrogel as an osteogenic\/antibiotic delivery system in OM treatment.<\/jats:p>","DOI":"10.1002\/jbm.b.34824","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T04:55:50Z","timestamp":1616388950000},"page":"1677-1688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Local treatment of experimental mandibular osteomyelitis with an injectable biomimetic gentamicin hydrogel using a new rabbit model"],"prefix":"10.1002","volume":"109","author":[{"given":"Ahmed Maher","family":"Eltawila","sequence":"first","affiliation":[{"name":"Department of Materials Science Institute of Graduate Studies and Research, Alexandria University  Alexandria Egypt"},{"name":"Dental Biomaterials Department Faculty of Oral and Dental Medicine, Delta University for Science and Technology  Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Nageeb","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Materials Science Institute of Graduate Studies and Research, Alexandria University  Alexandria Egypt"},{"name":"Department of Dental Biomaterials Faculty of Dentistry, Alexandria University  Alexandria Egypt"},{"name":"Department of Clinical Dentistry Faculty of Medicine, University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimaa Mohamed","family":"Safaan","sequence":"additional","affiliation":[{"name":"Department of Materials Science Institute of Graduate Studies and Research, Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9282-8504","authenticated-orcid":false,"given":"Ahmed","family":"Abd El\u2010Fattah","sequence":"additional","affiliation":[{"name":"Department of Materials Science Institute of Graduate Studies and Research, Alexandria University  Alexandria Egypt"},{"name":"Department of Chemistry College of Science, University of Bahrain  Sakhir Kingdom of Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Zakaria","sequence":"additional","affiliation":[{"name":"Department of Biomedical Dental Sciences College of Dentistry, Imam Abdulrahman Bin Faisal University  Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Labiba K.","family":"El\u2010Khordagui","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Faculty of Pharmacy, Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif","family":"Kandil","sequence":"additional","affiliation":[{"name":"Department of Materials Science Institute of Graduate Studies and Research, Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-019-0061-z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.10.017"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina47070054"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90373-X"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-28766-7_2"},{"issue":"4","key":"e_1_2_9_7_1","first-page":"1066","article-title":"Diagnosis and treatment of osteomyelitis of the jaw\u2013a systematic review (2002\u20102015) of the literature","volume":"3","author":"Gudmundsson T","year":"2017","journal-title":"J Dentist Oral Disorders"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2019.01.036"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.02.005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2006.08.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.09.050"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz181"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12814"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.12.012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01626"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453670902884700"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2007.08.020"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.98B9.38057"},{"key":"e_1_2_9_19_1","first-page":"84","article-title":"In vivo efficiency of antimicrobial inorganic bone grafts in osteomyelitis treatments","volume":"97","author":"Mestres G","year":"2019","journal-title":"Korean J Couns Psychother"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41808"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.2016-338"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.09.040"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.17.01140"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11030116"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36790"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2017.02.031"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214167"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(10)80142-9"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36728"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0143-2885.2007.01230.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2015.03.053"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10971-015-3753-x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.50.1201"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14247"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12010176"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/15421406.2012.635530"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-019-00666-7"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12010093"},{"key":"e_1_2_9_39_1","volume-title":"Hydroxyapatite Dental Material","author":"Habibah TU","year":"2020"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34397"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma9040267"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34437"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1515\/bmt-2018-0044"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-019-2635-8"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.182102"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020551"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir842"},{"key":"e_1_2_9_48_1","first-page":"1027","article-title":"Diagnosis and management of osteomyelitis","volume":"84","author":"Hatzenbuehler J","year":"2011","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.2010-098"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.34824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.b.34824","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.34824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T15:09:10Z","timestamp":1693321750000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.34824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,21]]},"references-count":48,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1002\/jbm.b.34824"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.34824","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,21]]},"assertion":[{"value":"2020-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}