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However, all the approaches were always companied with complications and devastatingly subjected to relapse, which indicated the urgently need of an effective treatment method. In this project, a new hydrogel composed of Poly (\u03b3\u2010glutamic acid) (\u03b3\u2010PGA), Chitooligo\u2010saccharide, and Papain was developed via crosslinker (EDC&amp;NHS), and characterized with good porously three\u2010dimensional network structure, good water absorption, and mechanical properties. Besides, G\/C\/P hydrogel facilitated cell adhesion and inhibited excessive proliferation of fibroblasts, which indicated the potential of in vivo application. After applied onto skin wound healing in vivo on a rabbit ear skin wound model, G\/C\/P hydrogel inhibited excessive collagen deposition and the generation of hyperplastic scars effectively during wound healing. The hydrogel described here provide a new platform for regeneration field and hold great promise for solving serious skin disorder.<\/jats:p>","DOI":"10.1002\/jbm.b.34830","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T06:47:02Z","timestamp":1616136422000},"page":"1724-1734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Poly (\u03b3\u2010glutamic acid)\/chitooligo\u2010saccharide\/papain hydrogel prevents hypertrophic scar during skin wound healing"],"prefix":"10.1002","volume":"109","author":[{"given":"Yueming","family":"Xue","sequence":"first","affiliation":[{"name":"Key Laboratory of Bioactive Materials for Ministry of Education, College of Life Sciences Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiao","family":"Qi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials for 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