{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:25:10Z","timestamp":1790205910350,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201706990017"],"award-info":[{"award-number":["201706990017"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Zinc is emerging as a promising biodegradable metal for temporary implant applications. In this work, we investigate the influence of bovine serum albumin (BSA)\u2014the most abundant blood protein in simulated body fluid (SBF) on degradation of pure Zn via electrochemical measurements and long\u2010term immersion. Electrochemical experiments indicate a decrease of the corrosion rate of bare Zn with increasing BSA concentration in solution for short\u2010term exposures. Samples were characterized with scanning electron microscope (SEM) (including energy dispersive spectroscopy [EDS], X\u2010ray photoelectron spectroscopy [XPS], Fourier transform infrared spectroscopy [FTIR], and time\u2010of\u2010flight secondary ion mass spectrometry [TOF\u2010SIMS]) after immersion up to 21\u2009days. Presence of BSA in the electrolyte, decrease the amount of Ca\u2010phosphate precipitation on Zn surface. However, a more compact surface layer formed in the presence of BSA in solution. Most noteworthy, in long\u2010term exposures, BSA enhances localized corrosion of Zn\u2014such detrimental localized attack was not observed in BSA\u2010free solution. We suggest that a sealed space forming between the Zn substrate and a protein adsorption layer restricts mass transport, thus triggering localized corrosion of Zn.<\/jats:p>","DOI":"10.1002\/jbm.b.34901","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T08:32:11Z","timestamp":1625214731000},"page":"185-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Influence of bovine serum albumin on biodegradation behavior of pure Zn"],"prefix":"10.1002","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7779-9733","authenticated-orcid":false,"given":"Hongzhou","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering Institute for Surface Science and Corrosion, University of Erlangen\u2010N\u00fcrnberg  Erlangen 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