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Thus, ECM could be an ideal biomaterial for fabricating the scaffold. However, oxidative stress and biofilm formation at the wound site remains a major challenge that could be neutralized using herbal ingredients (e.g., curcumin). In this study, ECM was extracted from the biowaste of the goat abattoir by using decellularization. The goat small intestine submucosa (G\u2010SIS) is decellularized to obtain the decellularized G\u2010SIS (DG\u2010SIS) and curcumin (in different concentrations) was incorporated in the DG\u2010SIS to fabricate curcumin\u2010embedded DG\u2010SIS scaffolds. Changes brought by increasing the concentrations of the curcumin in DG\u2010SIS were observed in various properties, including free radical scavenging and antibacterial properties. Results depicted that the scaffolds are porous, biodegradable, biocompatible, antibacterial, and hydrophilic and showed sustained release of curcumin. Besides, it showed free radicals scavenging property. The porosity and hydrophilicity of the scaffolds were decreased with an increase in the curcumin content. However, biodegradability, free radical scavenging, biocompatibility, and antibacterial properties of the scaffolds increased with an increase in the curcumin content. The DG\u2010SIS scaffold containing 1\u2009wt % of curcumin may be a potential biomaterial for wound\u2010healing and skin tissue engineering.<\/jats:p>","DOI":"10.1002\/jbm.b.34903","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T07:03:40Z","timestamp":1626159820000},"page":"210-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Curcumin in decellularized <scp>goat small intestine submucosa<\/scp> for wound healing and skin tissue engineering"],"prefix":"10.1002","volume":"110","author":[{"given":"Hemant","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Polymer and Process Engineering Indian Institute of Technology Roorkee  Roorkee India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv Dutt","family":"Purohit","sequence":"additional","affiliation":[{"name":"Department of Polymer and Process Engineering Indian Institute of Technology Roorkee  Roorkee India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Bhaskar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Medical Engineering National Institute of Technology Rourkela  Rourkela India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Polymer and Process Engineering Indian Institute of Technology Roorkee  Roorkee India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakchi","family":"Bhushan","sequence":"additional","affiliation":[{"name":"Department of Polymer and Process Engineering Indian Institute of Technology Roorkee  Roorkee India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh Kumar","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Medical Engineering National Institute of Technology Rourkela  Rourkela India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayan Chandra","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Polymer and Process Engineering Indian Institute of Technology Roorkee  Roorkee India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"39","volume-title":"Human Wounds and Its Burden: An Updated Compendium of Estimates","author":"Sen CK","year":"2019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.04.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527652273.ch24"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9100648"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma12040641"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S165440"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10667857.2018.1432171"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2020.1793872"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.08.016"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S219224"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods6100092"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11706-014-0270-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12102286"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/106570"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NJ01594F"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-015-9863-0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2020.110237"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/abdb74"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-018-0023-x"},{"issue":"21","key":"e_1_2_8_21_1","first-page":"8197","article-title":"Skin tissue engineering: principles and advances","volume":"21","author":"Dhasmana A","year":"2018","journal-title":"J Dermatol Ski"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.01.037"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1163\/092050610X551943"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres\/2009031"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21988"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2013.05.045"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.12.038"},{"key":"e_1_2_8_28_1","unstructured":"BadylakSF FreytesDO.Extracellular matrix\u2010derived gels and related methods. 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