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The first originality of this study is to start from real wear particles obtained by the hip walking simulator (CERsim). These particles were compared with particles obtained by usual methods to assess the biocompatibility of materials: press machine (CERpress). Two ranges of ceramic particles were thus observed: ceramic particles with micron (intergranular fractures) and nano sizes (intragranular fractures), and characterized compared to ultra\u2010high molecular weight polyethylene (UHMWPE). The second originality of this work is to assess the cellular reaction using the primary joint chondrocyte cultures simulating the osteogenesis process and not the cell lines, which are used to simulate the biological reaction of osteolysis. The first results showed a significant difference in cell viability between the cells in contact with particles from the walking simulator and those obtained with the press machine. On the other hand, it was found that the way of extraction of the particles from the lubricant could significantly affect the biological reaction. More interestingly, nano\u2010sized ceramic particles showed a significant impact on the secretion of functional inflammatory mediators, agreeing with recent results in vivo. These novel methods of characterizing the osteogenic impact of <jats:italic>UHMWPE<\/jats:italic> and ceramic wear debris can complement the conventional expertise method focusing previously on the osteolysis aspect.<\/jats:p>","DOI":"10.1002\/jbm.b.34910","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T12:49:46Z","timestamp":1626871786000},"page":"338-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Nano\/micro implant debris affect osteogenesis by chondrocytes: Comparison between ceramic and UHMWPE from hip walking simulator"],"prefix":"10.1002","volume":"110","author":[{"given":"Marwa","family":"Ben Braham","sequence":"first","affiliation":[{"name":"Univ Lyon, INSA\u2010Lyon, CNRS UMR5259, LaMCoS  Villeurbanne France"},{"name":"University of Tunis El Manar, National Engineering School of Tunis  Tunis Tunisia"},{"name":"University of Carthage, National Institute of 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