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The present study focused on the synthesis and characterization of a hybrid hydrogel scaffold system poly(propylene\u2010fumarate)\u2010alginate\u2010polyvinyl alcohol\u2010acrylic acid (PAPA) using poly(propylene\u2010fumarate) (PPF), alginate, polyvinyl alcohol (PVA) and acrylic acid and the in vitro investigation of bidirectional mobility of swine shoulder tenocytes (SST) for its potential application in rotator\u2010cuff tendon regeneration. IR analysis revealed the presence of alginate, PPF and PVA segments on the surface, SEM and AFM analyses revealed the porous and nano\u2010topographical features of PAPA, respectively, swelling was 712.6\u2009\u00b1\u200984.21% with the EWC (%) of 87.59\u2009\u00b1\u20091.26 having the diffusional exponent and swelling constant 0.551 and 1.8, respectively. PAPA was biodegradable, cytocompatible and supported long\u2010term survival of SSTs. SEM imaging revealed the adhesion, colonization, and sheet formation of SSTs within the PAPA hydrogel network. The SSTs seeded on the PAPA scaffolds were peculiar for their bidirectional migration as the anterograde movement was completed in 9\u2009days whereas the retrograde infiltration occurred up to the depth of 198\u2009\u03bcm. These findings suggest the promising translational potential of PAPA scaffold system in the management of rotator cuff tendon injury.<\/jats:p>","DOI":"10.1002\/jbm.b.34924","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T16:43:18Z","timestamp":1628008998000},"page":"467-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hybrid interpenetrating hydrogel network favoring the bidirectional migration of tenocytes for rotator cuff tendon regeneration"],"prefix":"10.1002","volume":"110","author":[{"given":"Finosh G.","family":"Thankam","sequence":"first","affiliation":[{"name":"Department of Translational Research Western University of Health Sciences  Pomona California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connor","family":"Diaz","sequence":"additional","affiliation":[{"name":"Departments of Clinical &amp; Translational Science and Orthopedic 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