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However, its bioinert property is always the main concern, which could lead to poor osseointegration and subsequent clinical failure of the implant. Changing the surface structure to porous structure and mixing it with bioactive hydroxyapatite (HA) are the common methods, which could be used to enhance the properties of the PEEK\u2010based implants. In this study, friction stir processing was utilized for the fabrication of porous HA\/PEEK surface nanocomposite. Scanning electron microscopic image of the nanocomposite surface showed nano\u2010scale roughness of the porous structure. Water contact angle test confirmed the increase in the wettability of the treated specimens. In vitro bioactivity test via simulated body fluid solution, initial cell adhesion, cell proliferation, and cell differentiation assay also confirmed the enhancement in bioactivity of the treated surface in comparison to the bare PEEK. This surface modification method requires no special equipment and would not damage the heat\u2010sensitive PEEK substrate due to the low temperature used during the fabrication process.<\/jats:p>","DOI":"10.1002\/jbm.b.34964","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T19:15:50Z","timestamp":1637176550000},"page":"838-847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fabrication and in vitro study of<scp>3D<\/scp>novel porous hydroxyapatite\/polyether ether ketone surface nanocomposite"],"prefix":"10.1002","volume":"110","author":[{"given":"Davood","family":"Almasi","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering Imam Reza University of Applied Science and Technology Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woei Jye","family":"Lau","sequence":"additional","affiliation":[{"name":"School of Chemical 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