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Ethylene glycol dimethacrylate (EGDMA) with internal ester bond linkages and EGEMA discs were prepared in a polytetrafluoroethylene (PTFE) mold using 40\u2009\u03bcl macromer and photo\/co\u2010initiator mixture cured for 40\u2009s at 1000\u2009mW\/cm<jats:sup>2<\/jats:sup>. The discs were stored in the constant presence of <jats:italic>Streptococcus mutans<\/jats:italic> (<jats:italic>S. mutans<\/jats:italic>) in Todd Hewitt Yeast + Glucose (THYE+G) media up to 9\u2009weeks (<jats:italic>n<\/jats:italic>\u00a0=\u00a08 for each macromer type) and physical\/mechanical properties were assessed. Initial measurements EGEMA versus EGDMA polymer discs showed equivalent degree of conversion (45.69%\u2009\u00b1\u20092.38 vs. 46.79%\u2009\u00b1\u20094.64), diametral tensile stress (DTS; 8.12\u00b1\u20092.92\u2009MPa vs. 6.02\u2009\u00b1\u20091.48\u2009MPa), and low subsurface optical defects (0.41%\u2009\u00b1\u20090.254% vs. 0.11%\u2009\u00b1\u20090.074%). The initial surface wettability (contact angle) was slightly higher (<jats:italic>p<\/jats:italic>\u2009\u2264\u2009.012) for EGEMA (62.02\u00b0\u2009\u00b1\u20093.56) than EGDMA (53.86\u00b0\u2009\u00b1\u20095.61\u00b0). EGDMA showed higher initial Vicker's hardness than EGEMA (8.03\u2009\u00b1\u20090.88\u2009HV vs. 5.93\u2009\u00b1\u20090.69\u2009HV; <jats:italic>p<\/jats:italic>\u2009\u2264\u2009.001). After 9\u2009weeks of <jats:italic>S. mutans<\/jats:italic> exposure, EGEMA (\u0394DTS\u20141.30\u2009MPa) showed higher resistance to biodegradation effects with a superior DTS than EGDMA (\u0394DTS\u20146.39\u2009MPa) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0039). Visible and scanning electron microscopy images of EGEMA show less surface cracking and defects than EGDMA. EGDMA had higher loss of material (18.9% vs. 8.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0009), relative changes to fracture toughness (92.5% vs. 49.2%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0022) and increased water sorption (6.1% vs. 1.9%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0022) compared to EGEMA discs. The flipped external ester group linkage design is attributed to EGEMA showing higher resistance to bacterial degradation effects than an internal ester group linkage design methacrylate.<\/jats:p>","DOI":"10.1002\/jbm.b.34972","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T17:47:25Z","timestamp":1638467245000},"page":"991-1000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A novel methacrylate derivative polymer that resists bacterial cell\u2010mediated biodegradation"],"prefix":"10.1002","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1008-8638","authenticated-orcid":false,"given":"Dhiraj","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Surgical and Developmental Sciences, School of Dentistry University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4924-743X","authenticated-orcid":false,"given":"Debarati","family":"Ghose","sequence":"additional","affiliation":[{"name":"Department of Surgical and Developmental Sciences, School of Dentistry University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Bolskar","sequence":"additional","affiliation":[{"name":"TDA Research Inc.  Wheat Ridge Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8998-7563","authenticated-orcid":false,"given":"Isha","family":"Mutreja","sequence":"additional","affiliation":[{"name":"Minnesota Dental Research Center for Biomaterials and Biomechanics, Department of Restorative Sciences, School of Dentistry University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9213-3657","authenticated-orcid":false,"given":"Robert S.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Surgical and Developmental Sciences, School of Dentistry University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510372885"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.04.014"},{"key":"e_1_2_8_4_1","first-page":"201","article-title":"Effect of biofilm exposure on marginal integrity of composite restorations","volume":"33","author":"Mushashe AM","year":"2020","journal-title":"Am J Dent"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2012.06.013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300105"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856203768366558"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34313"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.02.020"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519858975"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2009.03.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2017.05.015"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2016.11.007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165760"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.09.050"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2012.05.024"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.17796\/1053-4628-41.3.225"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514544217"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00947"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2010.01296.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2019.09.004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2018.09.039"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(96)85912-6"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.3008"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2020.09.005"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215895"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33517"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1116\/1.5058072"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr00039a007"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja042491j"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)97635-4"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33435"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(96)01626-4"},{"key":"e_1_2_8_34_1","unstructured":"MaierA UhlA. 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