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However, they can be cytotoxic and alter the redox balance depending on the amounts of Cd<jats:sup>2+<\/jats:sup> adsorbed on their surface. Thus, the present study aimed to evaluate whether increases in selenium concentration in the synthesis of CdSe\u2010MSQDs decrease the oxidative stress caused by Cd<jats:sup>2+<\/jats:sup>\u2010based quantum dots. CdSe\u2010MSQDs synthesized with different concentrations of selenium were investigated against oxidative stress in the brain of chicken embryos by examining total antioxidant capacity, lipid peroxidation, thiol, and glutathione contents, as well as the activities of glutathione peroxidase, superoxide dismutase (SOD), catalase (CAT), and glutathione reductase. In addition, the vascularization of the chorioallantoic membrane (CAM) analysis was performed. Higher selenium concentrations alter the surface defect levels (decrease free Cd<jats:sup>2+<\/jats:sup>) and controlled the oxidative effects of CdSe\u2010MSQDs by reducing the lipid peroxidation, restoring the glutathione defense system and the antioxidant enzymes SOD and CAT, and maintaining the vascular density of the CAM. The current findings reinforce the study of the effects of the presence of Cd<jats:sup>2+<\/jats:sup> ions on the surface of quantum dots, changing toxicity, and aiming interesting strategies of nanomaterials in biological systems.<\/jats:p>","DOI":"10.1002\/jbm.b.34988","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T15:18:57Z","timestamp":1640013537000},"page":"1140-1150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Increased selenium concentration in the synthesis of <scp>CdSe<\/scp> m<scp>agic\u2010sized<\/scp> quantum dots affects how the brain responds to oxidative stress"],"prefix":"10.1002","volume":"110","author":[{"given":"Danielle Diniz","family":"Vilela","sequence":"first","affiliation":[{"name":"Biochemistry and Molecular Biology Laboratory Institute of Biotechnology, Federal University of Uberlandia  Uberlandia 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