{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:22:45Z","timestamp":1776770565523,"version":"3.51.2"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100015987","name":"Ministry of Textiles, Government of India","doi-asserted-by":"publisher","award":["4(3)\/7\u2010E\/2015\/TDS\/46"],"award-info":[{"award-number":["4(3)\/7\u2010E\/2015\/TDS\/46"]}],"id":[{"id":"10.13039\/501100015987","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, a ultra\u2010high molecular weight polyethylene (UHMWPE) braided structure was surface modified with low temperature plasma and was coated with cationized gelatin and hyaluronic acid to improve its biocompatibility for the reconstruction of an anterior cruciate ligament (ACL). The ligament was studied for its various mechanical properties. Surface modifications were studied through FESEM. Biological compatibility of the ligament was assessed in accordance to ISO 10993 standard. Tensile strength of the UHMWPE reconstructed ligament ranges between 2628 and 5937\u2009N; maximum tensile strength was attained in 1600 denier 2\/2 pattern of triple braided structure along with higher strain at failure of 36.1%. In 1600 denier 2\/2 pattern of triple braid structure, the linear stiffness was found to be high at 375\u2009N\/mm. Among the developed materials, four braided structures namely as 800 denier 2\/2 pattern of double braids and triple braids, 1600 denier 1\/1 pattern of double braid and 2\/2 pattern of triple braid were found to be mechanically suitable. Specifically, the 1600 denier 2\/2 pattern of triple braid having higher mechanical properties was selected for coating. The results of in\u2010vitro cytotoxicity and genotoxicity confirmed the extract of ACL to non\u2010toxic and non\u2010mutant. Furthermore, in\u2010vivo analysis of the extract and the coated ACL graft proved the ligament to be non\u2010irritant, non\u2010sensitizer and also found to promote new tissue formation around the graft. Based on the results, the CG and HA coated ACL graft were concluded to be biocompatible and having considerable potential as an alternate for autograft\/allograft.<\/jats:p>","DOI":"10.1002\/jbm.b.35001","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T11:41:30Z","timestamp":1640086890000},"page":"1306-1318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Development and assessment of biologically compatible anterior cruciate ligament using braided ultra\u2010high molecular weight polyethylene"],"prefix":"10.1002","volume":"110","author":[{"given":"Karuppuswamy","family":"Balasubramaniyan","sequence":"first","affiliation":[{"name":"Weaving and Knitting The South India Textile Research Association (SITRA) Coimbatore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnamoorthy","family":"Bhoobalan","sequence":"additional","affiliation":[{"name":"Weaving and Knitting The South India Textile Research Association (SITRA) Coimbatore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhasarathi","family":"Jayaraman","sequence":"additional","affiliation":[{"name":"Spinning, Weaving and Knitting The South India Textile Research Association (SITRA) Coimbatore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6508-516X","authenticated-orcid":false,"given":"Shanmugam","family":"Sounderraj","sequence":"additional","affiliation":[{"name":"Weaving and Knitting The South India Textile Research Association (SITRA) Coimbatore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K Rajendran","family":"Muthuukumar","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Medical Textiles The South India Textile Research Association (SITRA) Coimbatore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elango","family":"Santhini","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Medical Textiles The South India Textile Research Association (SITRA) Coimbatore India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801238-3.10999-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2005.07.009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compscitech.2015.03.017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","unstructured":"Wahed S.B.;Dunstan C.R.;Boughton P.A.;Ruys A.J.Biofunctionalization of UHMWPE polymer and its application in anterior cruciate ligament reconstruction.2020 71.","DOI":"10.20944\/preprints202008.0071.v1"},{"issue":"4","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/jbm.a.32801","article-title":"Aligned poly(L\u2010lactic\u2010co\u2010e\u2010caprolactone) electrospun microfibers and knitted structure: a novel composite scaffold for ligament tissue engineering","volume":"94","author":"Vaquette C","year":"2010","journal-title":"J Biomed Mater Res A"},{"issue":"6","key":"e_1_2_8_7_1","first-page":"1","article-title":"Mechanical and cytocompatibility evaluation of UHMWPE\/PCL\/bioglass\u00ae fibrous composite for acetabular labrum implant","volume":"16","author":"Anindyajati A","year":"2019","journal-title":"Materials"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM01703H"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200333050-00004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.07.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-012-1694-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116364"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31372"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.06.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.08.015"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2006.09.025"},{"key":"e_1_2_8_17_1","unstructured":"ISO 10993\u20105 Biological evaluation of medical devices \u2014 Part 5: Tests for in\u2010vitro cytotoxicity."},{"key":"e_1_2_8_18_1","unstructured":"ISO 10993\u20103:2014Biological evaluation of medical devices \u2014 Part 3: Tests for genotoxicity carcinogenicity and reproductive toxicity."},{"key":"e_1_2_8_19_1","unstructured":"ISO 10993\u20106 Biological evaluation of medical devices \u2014 Part 6: Tests for local effects after implantation."},{"key":"e_1_2_8_20_1","unstructured":"ISO 10993\u201010 Biological evaluation of medical devices \u2014 Part 10: Tests for irritation and skin sensitization."},{"key":"e_1_2_8_21_1","unstructured":"ISO 10993\u201011:2017 Biological evaluation of medical devices \u2014 Part 11: Tests for systemic toxicity."},{"key":"e_1_2_8_22_1","first-page":"53","article-title":"The effect of braiding parameters on the mechanical properties of braided ropes","volume":"14","author":"Omeroglu S","year":"2006","journal-title":"Fibre Text East Eur"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2009.07.019"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1060-1872(95)80011-5"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2006.03033.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.12.007"},{"issue":"2","key":"e_1_2_8_27_1","first-page":"134","article-title":"Fungal decontamination of fleshy fruit water washes by double atmospheric pressure cold plasma","volume":"44","author":"Ouf SA","year":"2016","journal-title":"Clean"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.04.048"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-017-2613-0"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.46428"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2478\/s11696-008-0076-1"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.09.031"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3993\/jfbi06201001"},{"issue":"1","key":"e_1_2_8_34_1","first-page":"3","article-title":"Insulin\u2010like growth factors and their binding proteins: biological actions","volume":"16","author":"Jones JI","year":"2004","journal-title":"Endocr Rev"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21496"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v6.i1.127"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22757"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13066"},{"key":"e_1_2_8_39_1","first-page":"153","article-title":"Enhancing the surface properties of a bioengineered anterior cruciate ligament matrix for use with point\u2010of\u2010care stem cell therapy","volume":"7","author":"Xiaohua Y","year":"2021","journal-title":"Res Tissue Eng"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603517749919"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-017-1743-6"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.35001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.b.35001","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.35001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T18:16:58Z","timestamp":1699985818000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.35001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,21]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1002\/jbm.b.35001"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.35001","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,21]]},"assertion":[{"value":"2021-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}