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Polymers were chemically cross\u2010linked with monomer (methacrylic acid) using methylene bisacrylamide as cross\u2010linking agent and ammonium per sulphate as a reaction initiator in aqueous medium. Developed hydrogels were characterized for morphology, physical existence, drug loading (%), compositional and structural analysis, thermal behavior and stability, drug release analysis (pH\u20091.2 and pH\u00a07.4), and in vivo release kinetics. pH sensitive behavior was established by observing swelling and release behavior at different pH values (1.2 and 7.4). Biocompatibility of network was evaluated through acute oral toxicity studies in rabbits. Results revealed that cytarabine was efficiently loaded in prepared hydrogels with an entrapment efficiency of 54.67%\u2013108.59%. Highest swelling ratio of 38.67 was noticed at pH\u00a07.4. Maximum pH sensitive behavior was seen at pH\u00a07.4 showing maximum drug release up to 94.51%. All developed formulations followed zero order release as confirmed from regression coefficient (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.9912\u20130.9991). In\u2010vivo studies confirmed enhanced bioavailability of cytarabine. Histopathological examination and hemocompatibility studies proved that developed hydrogel system was safe, biocompatible, nonhemolytic in nature exhibiting no symptoms of dermal, ocular toxicities, and no changes in biochemical parameters of blood and histology of key organs. So, developed hydrogel system can be employed as an excellent drug delivery device where controlled drug delivery is desired.<\/jats:p>","DOI":"10.1002\/jbm.b.35016","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T07:00:28Z","timestamp":1643612428000},"page":"1545-1562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["RETRACTED: Biocompatible polymeric blend for <scp>pH<\/scp> driven delivery of cytarabine: Effect of feed contents on swelling and release kinetics"],"prefix":"10.1002","volume":"110","author":[{"given":"Nighat","family":"Batool","sequence":"first","affiliation":[{"name":"College of Pharmacy, Faculty of Pharmacy University of Sargodha  Sargodha Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rai Muhammad","family":"Sarfraz","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Faculty of Pharmacy University of Sargodha  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