{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:47:41Z","timestamp":1755218861025,"version":"3.43.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cemented Spectron EF stem in combination with the cemented non\u2010crosslinked Reflection All\u2010Poly cup showed a high rate of mid\u2010term aseptic loosening. However, the failure mechanisms are not fully known. We assessed the inflammatory tissue reactions and wear particles in periprosthetic tissues, implant wear and blood metal ion levels in 28 patients with failed implants. Histological analysis showed a macrophage pre\u2010dominant pattern with randomly distributed lymphocytes, with various amounts of neutrophils and giant cells. The number of different cell types in the tissue samples from patients in the cup group and in the stem group was similar. Wear particles, mainly ZrO<jats:sub>2<\/jats:sub>, CoCrMo, and polyethylene particles of different sizes and shapes, were associated with macrophages\/giant cells, and total particle load\/mm<jats:sup>2<\/jats:sup> was higher in cases of stem loosening. The Spectron EF stems were heavily worn, abraded, and polished. Stem abrasion correlated with metal ion concentrations in blood. The median polyethylene wear rate of the Reflection cups was 0.23\u2009mm\/year. The high proximal roughness of the Spectron EF stem resulted in excessive cement wear during loosening. The resulting inflammatory tissue responses to the degradation products both from the cup and the stem led to massive osteolysis and subsequent implant loosening.<\/jats:p>","DOI":"10.1002\/jbm.b.35023","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T08:26:21Z","timestamp":1643617581000},"page":"1624-1636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Inflammatory tissue reactions around aseptically loose cemented hip prostheses: A retrieval study of the Spectron <scp>EF<\/scp> stem with Reflection <scp>All\u2010Poly<\/scp> acetabular cup"],"prefix":"10.1002","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7590-220X","authenticated-orcid":false,"given":"Susann","family":"Wolf","sequence":"first","affiliation":[{"name":"Biomatlab, Department of Orthopedic Surgery Haukeland University Hospital  Bergen Norway"},{"name":"National Institute of Occupational Health  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Christine","family":"Johannessen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Bergen  Bergen Norway"},{"name":"Department of Pathology Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ellison","sequence":"additional","affiliation":[{"name":"Biomatlab, Department of Orthopedic Surgery Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ove","family":"Furnes","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Bergen  Bergen Norway"},{"name":"The Norwegian Arthroplasty Register, Department of Orthopedic Surgery Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geir","family":"Hallan","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Bergen  Bergen Norway"},{"name":"The Norwegian Arthroplasty Register, Department of Orthopedic Surgery Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Rogg","sequence":"additional","affiliation":[{"name":"Biomatlab, Department of Orthopedic Surgery Haukeland University Hospital  Bergen Norway"},{"name":"Department of Clinical Medicine University of Bergen  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrine","family":"Skarstein","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Bergen  Bergen Norway"},{"name":"Department of Pathology Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul Johan","family":"H\u00f8l","sequence":"additional","affiliation":[{"name":"Biomatlab, Department of Orthopedic Surgery Haukeland University Hospital  Bergen Norway"},{"name":"Department of Clinical Medicine University of Bergen  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453674.2016.1222804"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200200002-00002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(99)90096-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000181145.01306.f9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-005-0066-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2014.05.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)92063-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.M.01573"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453670903161124"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21389"},{"issue":"2","key":"e_1_2_7_12_1","first-page":"182","article-title":"Biologic effects of implant debris","volume":"67","author":"Hallab NJ","year":"2009","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.94B1.28047"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453670610045902"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/00003086-197606000-00029","article-title":"The pathology of the joint tissues and its clinical relevance in prosthesis failure","volume":"117","author":"Mirra JM","year":"1976","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33243"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199608001-00017"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00958.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199612000-00006"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199072040-00008"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3928\/0147-7447-20010901-20"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.55.BJR-2016-0086"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2008.0142"},{"key":"e_1_2_7_24_1","first-page":"201","article-title":"The basic science of periprosthetic osteolysis","volume":"62","author":"Goodman SB","year":"2013","journal-title":"Instr Course Lect"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453670903473016"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00176"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12907-016-0025-9"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1372-y"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36057"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32183"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24579"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma12172771"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.5301\/hipint.5000481"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.01625"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155121"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2016.01.041"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197614"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.10299"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2017.04.016"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-012-2430-4"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199308000-00021"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1243\/095441105X63291"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.10078"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.35023","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.b.35023","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.35023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:35:24Z","timestamp":1754483724000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.35023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,31]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/jbm.b.35023"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.35023","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"type":"print","value":"1552-4973"},{"type":"electronic","value":"1552-4981"}],"subject":[],"published":{"date-parts":[[2022,1,31]]},"assertion":[{"value":"2021-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}