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A novel scaffold patch made with collagen and silk\u2010fibroin (COL\u2010SF) was further associated to polyaniline (PANi) to increase conductivity. Thus, this study investigated the safety of the association of PANi to a patch, and the improvement in LV remodeling in a myocardial infarct (MI) rat model. Wistar rats underwent MI induction. MI was confirmed with echocardiographic and after 2\u2009weeks, animals (<jats:italic>n\u2009=<\/jats:italic>\u00a010\/group) were randomized into: (a) COL\u2010SF hyaluronic acid patch, (b) PANi hyaluronic acid patch, (c) MI Control (just repeat thoracotomy). Healthy animals were also followed. Echocardiography was performed at pre\u2010treatment, and at 2\u2010, 4\u2010, and 8\u2010weeks post\u2010treatment. Hearts underwent hemodynamic evaluation on Langendorff apparatus and histology for LV thickness and percent of infarct size. Liver, kidneys, and blood samples were evaluated for biochemical, hematological, oxidative stress, and histology. There was a tendency of lower %infarct size in patched animals. LV thickness was higher in the patched animals than controls. Functional echocardiographic indices %Fractional shortening and %LV ejection fraction decreased in the MI control group, but not in the patched animals. PANi presented higher %LVEF versus MI control. PANi presented higher liver transaminases; no morphological changes were observed in histology. Elevation of antioxidant markers was observed. COL\u2010SF and PANi patches were able to induce better remodeling features compared to MI controls on %infarct size and LV thickness and have not presented echocardiographic worsening. Polyaniline may present a slight improvement on LV remodeling, despite associated to signs of hepatotoxicity and pro\u2010oxidant effect.<\/jats:p>","DOI":"10.1002\/jbm.b.35026","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T08:06:43Z","timestamp":1643616403000},"page":"1651-1666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of a collagen hyaluronic acid silk\u2010fibroin patch with the electroconductive element polyaniline on left ventricular remodeling in an infarct heart model"],"prefix":"10.1002","volume":"110","author":[{"given":"Fernanda Gomes","family":"Leite","sequence":"first","affiliation":[{"name":"Graduate Program in Pharmaceutical Sciences University of Sorocaba  Sorocaba Brazil"},{"name":"Toxicology Program University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana 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