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Therefore, effective treatment of bacterial infections is an urgent problem to be solved. In this article, a multifunctional therapeutic material with antibacterial properties was designed and synthesized. First, the porous media material ZIF\u20108 was synthesized, and applied to load hesperidin. When the load is completed, a layer of hyaluronic acid (HA) is uniformly wrapped on surface of the material. Such materials have high stability and high drug\u2010carrying capacity, and can be slowly released in vivo. The HA coated on surface can also promote penetration of active ingredients into cells and give full play to antibacterial ability. Results of in vitro and in vivo antibacterial tests show that synergy between the materials enhances antibacterial activity which is related to dose. The material achieves high\u2010efficiency antibacterial effects by increasing the permeability of cell membranes and destroying the integrity of bacteria. At same time, the material does not show obvious side effects. Therefore, the material seems to be a promising antibacterial agent with good biocompatibility and strong antibacterial activity.<\/jats:p>","DOI":"10.1002\/jbm.b.35046","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T10:41:04Z","timestamp":1646822464000},"page":"1887-1898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficient sterilization system combining flavonoids and hyaluronic acid with metal organic frameworks as carrier"],"prefix":"10.1002","volume":"110","author":[{"given":"Jie","family":"Yang","sequence":"first","affiliation":[{"name":"School of Life Sciences Anhui Agricultural University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaling","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Agricultural University  Hefei 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