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Polyether ether ketone (PEEK) has been widely used in spinal fusion and cranioplasty given its excellent biomechanical properties, biocompatibility, and stability. The typical design method of femoral prosthesis is based on the contralateral mirror image model (M\u2010model), and we propose a novel method for designing femoral prosthesis, which is based on the cross section and centerline of the mirrored femur (C\u2010model). In this study, the femoral shaft prostheses based on two models were manufactured using fused deposition modeling technology, and we use mechanical test and finite element analysis (FEA) to reveal the differences in mechanical properties of the two models. The mechanical results showed that the maximum loading force and yield strength were increased by 3% and 6% in the C\u2010model prosthesis compared with the M\u2010model prosthesis, respectively. In FEA, the results indicate that the C\u2010model prosthesis could reduce the stress concentration by 5.4%\u201310.9% compared to the M\u2010model prosthesis. Finally, the 3D\u2010printed PEEK femoral shaft prosthesis based on C\u2010model was implanted, no early complications occurred. Postoperative radiological examination indicated that the prosthesis and the femoral osteotomy end were closely matched and fixed well.<\/jats:p>","DOI":"10.1002\/jbm.b.35055","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T05:48:53Z","timestamp":1647496133000},"page":"2006-2014","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Custom design and biomechanical clinical trials of <scp>3D<\/scp>\u2010printed polyether ether ketone femoral shaft prosthesis"],"prefix":"10.1002","volume":"110","author":[{"given":"Chao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Orthopedics Zigong Fourth People's Hospital  Zigong China"},{"name":"Digital Medical Center Zigong Fourth People's Hospital  Zigong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baifang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zigong Fourth People's Hospital  Zigong China"},{"name":"Department of Orthopedics Affiliated Hospital of Southwest Medical University  Luzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayan","family":"Deng","sequence":"additional","affiliation":[{"name":"Digital Medical Center Zigong Fourth People's Hospital  Zigong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danwei","family":"Shen","sequence":"additional","affiliation":[{"name":"Digital Medical Center Zigong Fourth People's Hospital  Zigong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zigong Fourth People's Hospital  Zigong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lun","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zigong Fourth People's Hospital  Zigong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Health Management Center Zigong Fourth People's Hospital  Zigong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guigang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Digital Medical Center Zigong Fourth People's Hospital  Zigong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3618"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.12659\/msm.902971"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010019\u20106236\u20106"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrx038"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2016.11.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016\u20100192"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010017\u20106240\u20105"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25297"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3928\/01477447\u201020140124\u201024"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957\u2010016\u20100852\u20102"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000001605"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2017.01.012"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018\u2010021\u201002374\u2010w"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018\u2010019\u20101097\u2010x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2019.09.001"},{"issue":"7","key":"e_1_2_9_17_1","first-page":"732","article-title":"Biomechanical comparison of internal fixations in osteoporotic intertrochanteric fracture. 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