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This study addressed the contemporary need for a conductive biomimetic nanocomposite scaffold for cardiac tissue engineering by examining the use of a gold nanoparticle\u2010incorporated porcine cholecystic extracellular matrix for the same. The scaffold had an electrical conductivity (0.74\u00a0\u00b1\u00a00.03\u00a0S\/m) within the range of native myocardium. It was a suitable substrate for the growth and differentiation of cardiomyoblast (H9c2) as well as rat mesenchymal stem cells to cardiomyocyte\u2010like cells. Moreover, as an epicardial patch, the scaffold promoted neovascularisation and cell proliferation in infarcted myocardium of rats. 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