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However, the effect of nerve repair is still limited, and only 50% of patients can recover useful functions. To overcome these obstacles, collagen\u2010coated poly(lactic\u2010co\u2010glycolic acid) (PLGA) conduits loaded with CBD\u2010IGF\u20101 were designed and tested in vitro and in vivo. The physical characterization of the conduit was tested by scanning electron microscopy, and the static water contact angle, release rate, and nerve regeneration ability of the conduit were verified in a rat sciatic nerve injury model. The results showed that the PLGA\/col\/CBD\u2010IGF\u20101 conduit had a rough surface and good hydrophilicity. CBD\u2010IGF\u20101 could be released slowly from the PLGA\/col\/CBD\u2010IGF\u20101 conduit. In the in vivo experiment, gait analysis and electrophysiological evaluation showed that the sciatic functional index and electrophysiological parameters were best in the group treated with the PLGA\/col\/CBD\u2010IGF\u20101 conduit. The pathological examination results for the sciatic nerve and gastrocnemius muscle in the group treated with the PLGA\/col\/CBD\u2010IGF\u20101 conduit were better than those in the other three groups. In short, this study demonstrated the beneficial effects of CBD\u2010IGF\u20101 in nerve regeneration. The PLGA\/col\/CBD\u2010IGF\u20101 conduit has therapeutic potential for use in the treatment of PNI.<\/jats:p>","DOI":"10.1002\/jbm.b.35064","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T05:19:40Z","timestamp":1650431980000},"page":"2100-2109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effect of poly(lactic\u2010co\u2010glycolic acid) conduit loading insulin\u2010like growth factor 1 modified by a <scp>collagen\u2010binding<\/scp> domain on peripheral nerve injury in rats"],"prefix":"10.1002","volume":"110","author":[{"given":"Jun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedics The Second Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Second Hospital of Jilin 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