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With the accelerating use of increasingly wear\u2010resistant biomaterials, identifying such particles and evaluating their biological response is becoming more challenging. Highly sensitive wear particle isolation methods have been developed but these methods cannot isolate the complete spectrum of particle types present in individual tissue samples. Two established techniques were modified to create one novel method to isolate both high\u2010 and low\u2010density materials from periprosthetic tissue samples. Ten total hip replacement and eight total knee replacement tissue samples were processed. All particle types were characterized using high resolution scanning electron microscopy. UHMWPE and a range of high\u2010density materials were isolated from all tissue samples, including: polymethylmethacrylate, zirconium dioxide, titanium alloy, cobalt chromium alloy and stainless steel. This feasibility study demonstrates the coexistence of mixed particle types in periprosthetic tissues and provides researchers with high\u2010resolution images of clinically relevant wear particles that could be used as a reference for future in vitro biological response studies.<\/jats:p>","DOI":"10.1002\/jbm.b.35076","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T12:01:21Z","timestamp":1652097681000},"page":"2276-2289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements"],"prefix":"10.1002","volume":"110","author":[{"given":"Ashley A.","family":"Stratton\u2010Powell","sequence":"first","affiliation":[{"name":"Institute of Medical and Biological Engineering, School of Mechanical Engineering University of Leeds  Leeds 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