{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T09:37:18Z","timestamp":1784885838886,"version":"3.55.0"},"reference-count":93,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008856","name":"Department of Health of Zhejiang Province","doi-asserted-by":"publisher","award":["2020KY624"],"award-info":[{"award-number":["2020KY624"]}],"id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008856","name":"Department of Health of Zhejiang Province","doi-asserted-by":"publisher","award":["2020RC023"],"award-info":[{"award-number":["2020RC023"]}],"id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently, a large number of studies have reported that lithium (Li) displayed a positive effect on osteogenesis. However, only a few studies have investigated the Li\u2010incorporated surfaces through electrochemical deposition. In this study, electrochemical deposition was conducted on a CHI600E electrochemical workstation. The characterization of electrochemical deposition (ECD) and ECD\u2010Li surfaces were detected by field\u2010emission scanning electron microscopy with energy\u2010dispersive spectrometer. rBMSCs were cultured on two surfaces for subsequent adhesion, proliferation and live\/dead assay. To evaluate the effects of Li\u2010incorporated implants by electrochemical deposition on osseointegration in vivo, teeth extraction of two premolars and one first molar in bilateral mandible were performed on six male beagle dogs. After 3\u00a0months, ZDI and ZDI\u2010Li implants were inserted into the bilateral mandible of each beagle dog. Micro Computed Tomography (Micro\u2010CT) and hard tissue sectioning analysis were carried out to evaluate the osseointegration at 4\u2010 and 8\u2010weeks post\u2010implantation. Results showed that ECD\u2010Li surface promoted adhesion and proliferation of BMSCs in the early stage. More importantly, through micro\u2010CT analysis, the values of bone volume\/total volume (BV\/TV) (0.374\u2009\u00b1\u20090.015), bone\u2010implant contact (BIC) (0.831\u2009\u00b1\u20090.025), and Tb.Th (0.412\u2009\u00b1\u20090.007) in ZDI\u2010Li group was significantly higher than those of ZDI group (0.302\u2009\u00b1\u20090.009, 0.700\u2009\u00b1\u20090.023, 0.353\u2009\u00b1\u20090.001, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01) at 4\u2009weeks. Similarly, ZDI\u2010Li group manifested more bone contact with the implant surfaces at 4\u2009weeks based on hard tissue sectioning analysis, whereas no significant difference was detected between two groups at 8\u2009weeks. Therefore, incorporating Li into implant surface through ECD could enhance early osseointegration in vivo.<\/jats:p>","DOI":"10.1002\/jbm.b.35085","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T12:00:21Z","timestamp":1653307221000},"page":"2399-2410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Electrochemical deposition of lithium coating on titanium implant with enhanced early stage osseointegration"],"prefix":"10.1002","volume":"110","author":[{"given":"Tingben","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Implantology, Stomatology Hospital, School of Stomatology Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University  Hangzhou Zhejiang 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