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Sodium alginate (SA) and silk fibroin (SF) are natural biomaterials, which are widely used in tissue engineering and other fields because of their low price, high safety, and good biocompatibility. However, SA itself degrades slowly, its degradation mode is difficult to control, and the degradation products are difficult to remove from the body because of its high molecular weight. Therefore, the composite scaffolds were prepared by freeze\u2010drying composite technology by using the Schiff base reaction between biocompatible SF and permeable oxidized sodium alginate (OSA). Sodium periodate was used as oxidant to modify SA. The results showed that higher oxidation degree of OSA could be obtained by increasing the proportion of oxidant, and the relative molecular weight of the oxidized products could also be reduced. The composite scaffolds were prepared by using sodium tetraborate as a crosslinking accelerator of the Schiff base reaction between OSA and SF. FT\u2010IR confirmed that the Schiff base group appeared in the material. In vitro biodegradation experiments showed that the biodegradation of the composite scaffolds was controllable, and the cytocompatibility experiment showed that the composite scaffolds had good biocompatibility.<\/jats:p>","DOI":"10.1002\/jbm.b.35119","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T08:09:46Z","timestamp":1656317386000},"page":"2667-2675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Oxidized sodium alginate crosslinked silk fibroin composite scaffold for skin tissue engineering"],"prefix":"10.1002","volume":"110","author":[{"given":"Yajin","family":"Guo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology  Wuhan People's Republic of China"},{"name":"International School of Materials Science and Engineering Wuhan University of Technology  Wuhan People's 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