{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:20Z","timestamp":1786977920814,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008982","name":"National Science Foundation of Sri Lanka","doi-asserted-by":"publisher","award":["1913847"],"award-info":[{"award-number":["1913847"]}],"id":[{"id":"10.13039\/501100008982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Stress urinary incontinence (SUI) impacts ~1\/3 of women over age 50. Negative publicity around PP meshes used in pelvic prolapse repair drives the need for identifying alternative biomaterials for SUI repair. Our study evaluated in vivo response to collagen sling implanted in an ovine model. Electrocompacted collagen threads were filament wound as slings and crosslinked in genipin. Collagen slings were implanted suburethrally mimicking the transvaginal tape technique. Main study groups were: Collagen sling (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03, 6\u00a0months) and PP sling (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03, 6\u00a0months). Collagen sling was also tested at 3\u2010weeks (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a01) to observe early\u2010stage tissue response and 1\u2010year (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a02) to assess biomaterial longevity in a preliminary capacity. Collagen slings healed to a fibrous ligament texture at 6\u2009months and maintained such texture to 1\u2009year. Histological scoring indicated biocompatible responses to collagen slings with no adverse events. All study groups exhibited complete tissue ingrowth and interstitial de novo collagen deposition at all time points. Collagen threads induced orderly de novo collagen deposition that was aligned along long axes of threads. Tissue infiltrated collagen slings that were explanted at 6 and 12\u2009months presented similar structural strength with native tissues such as vagina and fascia, and PP (Lynx) slings (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u2009.05). With the limitation of low number of animals per time point in hindsight, this preliminary study justifies evaluation of collagen slings in a larger sample size of animals, particularly to assess persistence of ligamentous tissue response over longer durations than 1\u2010year.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.35120","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T10:21:06Z","timestamp":1656757266000},"page":"2676-2685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A preliminary evaluation of in vivo response to a filament\u2010wound macroporous collagen midurethral sling in an ovine model"],"prefix":"10.1002","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1376-5697","authenticated-orcid":false,"given":"Ahmad O.","family":"Khalifa","sequence":"first","affiliation":[{"name":"Department of Urology, University Hospitals Cleveland Medical Center Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Urology Menoufia University  Shebeen El\u2010Kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8100-0971","authenticated-orcid":false,"given":"Ilaha","family":"Isali","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospitals Cleveland Medical Center Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Mechanical and Aerospace Engineering Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mastran","sequence":"additional","affiliation":[{"name":"CollaMedix Inc.  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"McClellan","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Callan","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subba","family":"Shankar","sequence":"additional","affiliation":[{"name":"CollaMedix Inc.  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T.","family":"MacLennan","sequence":"additional","affiliation":[{"name":"Department of Pathology Case Western Reserve University &amp; University Hospitals Case Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Pathology Case Western Reserve University &amp; University Hospitals Case Medical Center  Cleveland Ohio USA"},{"name":"Department of Biomedical Engineering Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrick R.","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences, School of Medicine Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozan","family":"Akkus","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering Case Western Reserve University  Cleveland Ohio USA"},{"name":"CollaMedix Inc.  Cleveland Ohio USA"},{"name":"Department of Biomedical Engineering Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Orthopedics Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adonis K.","family":"Hijaz","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospitals Cleveland Medical Center Case Western Reserve University  Cleveland Ohio USA"},{"name":"CollaMedix Inc.  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2006.https:\/\/www.iso.org\/standard\/61089.html."},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603514560655"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00121138"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0309324716668673"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.2003.07187.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(02)00173-2"},{"key":"e_1_2_9_37_1","first-page":"37","volume":"29","author":"Petros P.","year":"2010","journal-title":"Pelviperineology"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-006-0288-2"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2014.05.005"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10029-010-0731-7"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied 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